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The New England Patriots (6-6) and the Arizona Cardinals (4-8) will meet on Monday Night Football. This is the first game since 2020 between these teams. In that matchup, New England came out on top, 20-17. Heading into Monday Night Football, New England is 6-5-1 against the spread, while Arizona is 6-6. Both teams have lost two straight games and are in desperate need of a win to stay in the NFL playoff picture.

Kickoff is at 8:15 p.m. ET in Arizona. Caesars Sportsbook lists New England as a 2.5-point favorite, while the over/under, or total number of points Vegas thinks will be scored, is 44 in the latest Cardinals vs. Patriots odds. Before making any Patriots vs. Cardinals picks or NFL predictions, make sure you check out what SportsLine's resident Cardinals expert, Tom Fornelli, has to say.

A CBS Sports writer since 2010, Fornelli has crushed his Arizona selections, going 9-2 on his last 11 NFL picks on games involving the Cardinals, returning $676 for $100 players. Anybody who has followed him has seen huge returns. 

Now, Fornelli has set his sights on Cardinals vs. Patriots and just locked in his picks and NFL predictions. You can head to SportsLine now to see his picks. Now, here are several NFL odds and betting lines for Patriots vs. Cardinals:

  • Cardinals vs. Patriots spread: New England -2.5
  • Cardinals vs. Patriots over/under: 44 points
  • Cardinals vs. Patriots money line: New England -135, Arizona +115
  • NE: Patriots are 12-2 against the spread in their last 14 games following a double-digit loss at home
  • ARI: Cardinals are 5-2 ATS in their last seven games following a straight-up loss
  • Cardinals vs. Patriots picks: See picks at SportsLine

Why the Cardinals can cover

Receiver DeAndre Hopkins has had a major impact since returning to the field in Week 7. Hopkins owns a large catch radius, allowing him to make circus grabs over any defender. The five-time Pro Bowler is tied for first on the team in receptions (49) with a team-best 574 receiving yards. He's recorded 80-plus yards in three straight games.

Receiver Marquise Brown is another big-time weapon on the outside. Brown has the ability to race past cornerbacks with outstanding long speed. The Oklahoma product and quarterback Kyler Murray's former collegiate teammate has reeled in 49 passes for 531 yards and three touchdowns. He's also seen double-digit targets in four of his seven games played. See which team to pick here.

Why the Patriots can cover

Running back Rhamondre Stevenson is an impactful player in the run and pass game. Stevenson has been effective when he gets downhill and has the size (six-feet, 230 pounds) to break tackles. The Oklahoma product has soft hands coming out of the backfield, recording 383 receiving yards on the year. Stevenson has finished with 75-plus scrimmage yards in nine games thus far.

Quarterback Mac Jones has been an accurate passer who gets the ball out of his hands quickly. Jones can deliver the ball to all three levels on the field with ease and will take off to pick up easy yards on the ground. The Alabama product is completing 68% of his throws for 1,963 yards. He's tossed 240-plus yards with a passing score in two of his past three outings. See which team to pick here.

How to make Patriots vs. Cardinals picks

Fornelli has analyzed this matchup and, while we can tell you he's leaning Under on the point total, he has discovered a critical X-factor that has him jumping all over one side of the spread. He's only sharing what it is, and which side to back, at SportsLine.

Who wins Patriots vs. Cardinals on Monday Night Football? And which critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Patriots vs. Cardinals spread to back, all from the expert who is an outstanding 9-2 on picks involving Arizona, and find out.