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The Manchester United Red Devils will continue their quest for a trophy against AS Roma on Thursday in a 2020-21 UEFA Europa League semifinal match. The first leg is at Old Trafford, where Man U is 16-5-6 in all competitions this season, and United has lost just once in its last 21 matches overall. It sits firmly in second place in the English Premier League, 10 points behind Manchester City, and was eliminated from the Champions League, but it is playing at an elite level and takes on a Roma squad that is seventh in Italy's Serie A.

Kickoff from Manchester, England, is scheduled for 3 p.m. ET on Paramount+. United is the 1.5-goal and -200 money-line favorite (risk $200 to win $100) in the latest Roma vs. Manchester United odds from William Hill Sportsbook and the over-under for total goals scored is 2.5. Before finalizing any Manchester United vs. Roma picks, be sure to see the UEFA Europa League predictions and betting advice from SportsLine's soccer guru Martin Green.

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After working in the sports betting industry for several years, Green became a professional sports writer and handicapper. Since then, his European soccer picks have been spot-on. Green has generated $19,000 for $100 bettors since the 2017-18 season.

Now, Green has set his sights on Manchester United vs. Roma. You can head to SportsLine to see his picks. Here are several odds and trends for Roma vs. Manchester United:

  • Roma vs. Manchester United spread: Man United -1.5 (+130) 
  • Roma vs. Manchester United over-under: 2.5 goals
  • Roma vs. Manchester United money line: Roma +550, Man United -200, Draw +333 
  • MAN: Bruno Fernandes has 17 goals and 11 assists in 30 Europa League matches
  • ROM: Edin Dzeko has scored five goals in his previous four matches at Old Trafford

Why you should back Manchester United

The Red Devils are plus-27 in goal differential in the EPL, while Roma is just plus-7 in the Italian league. The Giallorossi have lost eight of 16 road games in league play, with a minus-10 goal differential. They have allowed a goal in seven straight, yielding 12 total in those matches, and Man U has a lot of firepower. Bruno Fernandes can do it all, scoring 24 goals and adding 14 assists across all competitions, and he ranks in the top three in the EPL in both categories. Marcus Rashford also is a dangerous option, scoring 20 goals and adding 12 assists.

Roma is winless in its last four Serie A games, while United has not lost in its last 14 EPL matches. Edinson Cavani (10 goals) and Paul Pogba (five goals, seven assists) also are difference-makers, and the back line is stout. The Red Devils allow just over a goal per game while Roma yields more than 1.5. Harry Maguire, Luke Shaw and Aaron Wan-Bissaka have combined for five goals and 10 assists and are elite defenders. Goalkeepers David de Gea and Dean Henderson compete for time but have combined for 24 clean sheets in 54 matches.

Why you should back Roma

The Giallorossi are two games away from their first European final in 30 years. Roma is second in the Europa League in goals with 26, and Borja Mayoral is tied for the lead with seven in the competition. The squad should come in rested after most of the top players sat out Saturday's setback against Cagliari, and it has beaten quality sides like Ajax and Shakhtar. Roma has lost once in the Europa League, in its final group-stage game after outscoring its first five opponents 13-2. 

Edin Dzeko, Jordan Veretout and Henrikh Mkhitaryan all have scored 11 times in all competitions and are among the seven Roma players with at least five goals. Mkhitaryan and Lorenzo Pellegrini are the primary distributors, combining for 16 assists in all competitions, and Pellegrini has scored eight goals. The Giallorossi are averaging nearly 12 shots per game, so the Man U goalkeepers (72.1 save percentage) could face a test. Roma has scored in six of its past seven road games, and United has conceded in three of its last five matches overall.  

How to make Europa League picks for Roma vs. Manchester United

Green is going under on the total, and he's identified an x-factor that has him jumping all over one side. He's also locked in a prop bet that returns plus money. Head to SportsLine to see his analysis and top picks.

So who wins Manchester United vs. Roma? And where does all the betting value lie? Visit SportsLine now to find out which side of the Roma vs. Manchester United money line has all the value, all from the European soccer expert who has generated $19,000 for $100 bettors since the 2017-18 season, and find out.