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The 2022 NCAA Tournament will be the last for Duke Blue Devils head coach Mike Krzyzewski and the five-time national champion is in the hunt once again. On Thursday night, the Blue Devils will take on the Texas Tech Red Raiders in a Sweet 16 matchup in the West Region. Duke is the No. 2 seed and has knocked off No. 15 seed Cal State Fullerton and No. 7 seed Michigan State, while Texas Tech is the No. 3 seed who defeated No. 14 seed Montana State and No. 11 seed Notre Dame.

The regional semifinal will be played at the Chase Center in San Francisco and tipoff is scheduled for 9:39 p.m. ET on CBS. The game is currently listed as a pick'em and the over-under for total points is 137.5 in the latest Duke vs. Texas Tech odds from Caesars Sportsbook. Before finalizing any Texas Tech vs. Duke picks, be sure to check out the college basketball predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $1,300 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Duke vs. Texas Tech and revealed its coveted picks and predictions for the NCAA Tournament 2022. You can head to SportsLine to see all of the model's college basketball picks. Here are several college basketball odds and trends for Texas Tech vs. Duke:

  • Duke vs. Texas Tech spread: PIck'em
  • Duke vs. Texas Tech over-under: 137.5 points
  • Duke vs. Texas Tech money line: TTU -110, Duke -110
  • Duke: The Blue Devils are 3-8 against the spread in the last 11 games
  • Texas Tech: The Red Raiders are 6-5 against the spread in the last 11 games

Why Duke can cover

The stars have certainly seemed to align for Coach K in his final season, as he landed the No. 2 overall recruit in the Class of 2021 (Paolo Banchero) and had the No. 6 overall class in the country. Banchero has blossomed into a star, averaging 17.0 points, 7.9 rebounds and 3.2 assists per game and he's shooting 63.3 percent from the floor in his last four games.

Krzyzewski bested long-time rival Tom Izzo in the second round and the Blue Devils looked extremely efficient in the process. They shot 57.1 percent from the floor and had five players reach double-figures scoring. Duke beat Texas Tech 69-58, covering as 9.5-point favorites in a matchup in 2018 and Mark Adams was an assistant coach on that squad. With both squads playing similarly stylistically, that may be a good omen for Duke, even with the roster turnover.

Why Texas Tech can cover

Texas Tech has an underrated offensive attack, including a top-tier mark in converting 55.0 percent of 2-point attempts. However, the Red Raiders are clearly led by their defense, and Texas Tech is arguably the best defensive team in the tournament. The Red Raiders lead the country in adjusted defensive efficiency this season, and Notre Dame was held to only 53 points in the second round matchup. Texas Tech forces a turnover on 23.5 percent of defensive trips, No. 11 in the country, and the Red Raiders are near the top of the country in block rate (12.2 percent) and steal rate (11.9 percent). 

Texas Tech also contests shots at an elite level, with opponents shooting 44.0 percent on two-point attempts and 31.4 percent on three-point attempts. The Red Raiders also clean up well on the defensive glass, with opponents securing only 26.0 percent of missed shots this season. Duke is very good on offense, but the Blue Devils sometimes struggle to create free-throw attempts, falling below the national average in free throw creation rate.

How to make Texas Tech vs. Duke picks

SportsLine's model is leaning over on the point total, projecting the teams to combine for 141 points. The model also says one side of the spread hits well over 60 percent of the time. You can only see the model's pick at SportsLine.

So who wins Duke vs. Texas Tech? And which side of the spread hits well over 60 percent of the time? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that has crushed its college basketball picks, and find out.