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The Louisville Cardinals (12-16) hit the road to take on the Virginia Tech Hokies (18-11) will face off in an ACC clash at 9 p.m. ET on Tuesday, March 1 at Cassell Coliseum. Louisville has struggled as of late, dropping nine of its last 10 games. Virginia Tech is coming off a 71-70 win over Miami (FL) on Saturday, and has won eight of its last nine games.

Virginia Tech is favored by 10.5 points in the latest Virginia Tech vs. Louisville odds from Caesars Sportsbook, and the over-under is set at 132. Before making any Louisville vs. Virginia Tech picks, you need to see the college basketball predictions and betting advice from the red-hot computer simulation model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $1,700 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Virginia Tech vs. Louisville, and just locked in its picks and CBB predictions. You can head to SportsLine now to see the model's picks. Here are several college basketball odds and betting lines for Virginia Tech vs. Louisville:

  • Virginia Tech vs. Louisville spread: Virginia Tech -10.5
  • Virginia Tech vs. Louisville over-under: 132 points

What you need to know about Virginia Tech

Virginia Tech escaped with a win this past Saturday against the Miami (Fla.) Hurricanes by the margin of a single free throw, 71-70. Four players on the Hokies scored in the double digits: forward Keve Aluma (18), guard Sean Pedulla (17), guard Darius Maddox (13), and guard Hunter Cattoor (10).

Virginia Tech still has a chance to make a late season push for an NCAA Tournament bid, but can't afford any slip ups. Senior forward Keve Aluma leads the way for the Hokies, averaging 15.8 points and 6.6 rebounds per game. Virginia Tech is 15-14 against the spread in 2021-22.

What you need to know about Louisville

Meanwhile, the Cardinals have to be aching after a bruising 99-77 defeat to the Wake Forest Demon Deacons this past Saturday. A silver lining for U of L was the play of forward Sydney Curry, who had 28 points in addition to seven boards.

Louisville has struggled in conference play, posting a 6-12 record in ACC play thus far. Senior forward Malik Williams has been a bright spot for the Cardinals, averaging 9.3 points and 7.7 rebounds per game. Louisville is 9-18-1 against the spread in 2021-22.

How to make Louisville vs. Virginia Tech picks

The model has simulated Virginia Tech vs. Louisville 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the model's Virginia Tech vs. Louisville pick at SportsLine.

So who wins Virginia Tech vs. Louisville? And which side of the spread hits well over 50 percent of the time? Visit SportsLine to see which side of the Louisville vs. Virginia Tech spread to jump on, all from the advanced model that is up over $1,700 on its college basketball picks the last five-plus years, and find out.