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The No. 18 Missouri Tigers and the Kentucky Wildcats are set to square off in an SEC matchup at 7 p.m. ET on Wednesday at Mizzou Arena. The Tigers are 11-3 overall and 6-1 at home, while Kentucky is 5-10 overall and 2-4 on the road. The Wildcats have won 11 of the last 12 in the series and covered in six of the last 10.

However, Kentucky is just 6-9 against the spread this season and Missouri has covered in four of the last five games against the Wildcats at home. The Tigers are favored by 4.5-points in the latest Missouri vs. Kentucky odds from William Hill Sportsbook, and the over-under is set at 137. Before entering any Kentucky vs. Missouri picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of almost $2,300 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Missouri vs. Kentucky. You can head to SportsLine to see its picks. Here are several college basketball odds for Missouri vs. Kentucky:

  • Missouri vs. Kentucky spread: Missouri -4.5
  • Missouri vs. Kentucky over-under: 137 points
  • Missouri vs. Kentucky money line: Missouri -200, Kentucky +175

What you need to know about Missouri

This past Saturday, Missouri narrowly escaped with a win as the squad sidled past the TCU Horned Frogs 102-98. Mizzou got double-digit scores from four players: Xavier Pinson (36), Jeremiah Tilmon (33), Javon Pickett (11), and Dru Smith (10).

Pinson is averaging 15.1 points and 3.4 assists per game this season, while Tilmon is averaging 13.9 points and 8.1 rebounds. The aggressive inside-outside combo has helped the Tigers get to the free-throw line 23.8 times per game this season, which is good for 14th-best in the nation. Kentucky will have to stay out of foul trouble to handle Cuonzo Martin's team on the road.

What you need to know about Kentucky

Meanwhile, Kentucky received a tough blow last week as the Wildcats fell 70-59 to the Alabama Crimson Tide. The top scorers for Kentucky were Olivier Sarr (12 points), Davion Mintz (12 points), and Dontaie Allen (12 points). The Wildcats looked like they might be finding their rhythm when they started the conference season with three consecutive wins but have since lost four of five. 

The Wildcats are 1-4 against the spread in their last five games, and they're 1-4 ATS in their last five meetings against Missouri on the road. 

How to make Missouri vs. Kentucky picks

The model has simulated Missouri vs. Kentucky 10,000 times and the results are in. We can tell you that the model is leaning under, and it also says one side of the spread has all the value. You can only see the pick at SportsLine.

So who wins Missouri vs. Kentucky? And which side of the spread has all the value? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that has crushed its college basketball picks, and find out.