Duke vs. Boston College prediction, odds: 2022 Week 10 college football picks, best bets by proven model
SportsLine's model just revealed its CFB picks, predictions, and best bets for Boston College Eagles vs. Duke Blue Devils on Friday

Alumni Stadium showcases an ACC matchup on Friday evening in Chestnut Hill. The Boston College Eagles host the Duke Blue Devils in the ninth game of the season for both teams. After three straight losses, Boston College is 2-6 this season and aiming to bounce back from a hiccup against UConn a week ago. Duke is 5-3 overall and coming off a bye week following a win over Miami. Boston College quarterback Phil Jurkovec (knee) is expected to miss this matchup.
Kickoff is set for 7 p.m. ET. The latest Duke vs. Boston College odds from Caesars Sportsbook list the Blue Devils as 11-point favorites. The over/under for total points is set at 47.5. Before finalizing any Boston College vs. Duke picks, you need to see the college football predictions and betting advice from SportsLine's advanced computer simulation model.
The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.
Now, the model has set its sights on Duke vs. Boston College and just locked in its picks and CFB predictions. You can head to SportsLine now to see the model's picks. Now, here are several college football odds and betting lines for Boston College vs. Duke:
- Duke vs. Boston College spread: Duke -11
- Duke vs. Boston College over/under: 47.5 points
- Duke vs. Boston College money line: Duke -440, Boston College +335
- DUKE: The Blue Devils are 5-3 against the spread this season
- BC: The Eagles are 1-7 against the spread this season
- Duke vs. Boston College picks: See picks here
Why Duke can cover
Duke's defense has been vulnerable at times this season, but this is a friendly matchup for the Blue Devils. Duke does have a strength in rushing defense, yielding only 3.8 yards per carry, and Boston College's offense is having a tough time overall in 2022. The Eagles have the second-fewest total yards (309.5 per game) in the ACC this season, and Boston College has the conference's worst running game. The Eagles are last in the ACC in rushing yards per game (67.5) and yards per carry (2.3), and Boston College is also in the bottom three of the conference in scoring (17.5 points per game) and third down conversion rate (30.4%).
On the other side, Duke is in the top four of the ACC in scoring offense (34.4 points per game), total offense (422.5 yards per game), rushing offense (205.1 yards per game), yards per carry (5.4), completion rate (64.6%) and sacks allowed (12). With Boston College also posting the second-worst scoring defense (28.8 points allowed per game) in the ACC, Duke has a clear path to efficiency and overall offensive success.
Why Boston College can cover
Boston College is scuffling this season, but there are avenues for potential success against Duke. On defense, the Eagles are allowing only 3.8 yards per carry this season, and that is key against a Duke offense that is reliant on rushing explosiveness. Boston College is also in the top four of the ACC in completion rate allowed at 57.9%, and Duke has the second-fewest passing yards (217.0 per game) in the ACC this season.
On the offensive side, Boston College faces a Duke defense that ranks in the bottom three of the conference in total yards allowed (392.8 per game). The Blue Devils are also second-worst in the conference in passing defense, yielding 262.9 yards per game, and Duke has allowed 16 touchdown passes, second-most in the ACC. Boston College is in the top five of the ACC in passing offense, averaging 242.0 yards per game, and senior wide receiver Zay Flowers is the most productive pass-catcher in the conference this season.
How to make Duke vs. Boston College picks
SportsLine's model is leaning Over on the total, with both teams projected to throw for more than 250 yards. The model also says one side of the spread has all the value. You can only see the model's pick at SportsLine.
So who wins Duke vs. Boston College? And which side of the spread has all the value? Visit SportsLine now to see which side of the Duke vs. Boston College spread you need to jump on Friday, all from the model that has crushed its college football picks, and find out.















