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Baseball fans could be seeing a preview of the National League Championship Series when the San Francisco Giants and Milwaukee Brewers open a three-game series on Friday at American Family Field in Milwaukee. The Giants (69-40) have the best record in baseball and have a four-game lead over the Brewers (65-44) for the best record in the NL. First pitch on Friday is at 8:10 p.m. ET. The Brewers are -157 money-line favorites in the latest Brewers vs. Giants odds from Caesars Sportsbook, while the Giants are +147 underdogs. 

The game is one of 15 on Friday's MLB schedule. Other matchups include the Phillies hosting the Mets in a matchup between the top two teams in the NL East and the White Sox and Cubs meeting in a Windy City clash. Before making any MLB picks or predictions on those games or others, you need to see what the SportsLine Projection Model has to say.

This model, which simulates every pitch of every game 10,000 times, is a profitable 140-113 on top-rated MLB money-line picks through 18 weeks in the 2021 season. It also had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line picks. Anyone following it has seen some huge returns.

Now, the model has crunched the numbers for the MLB schedule today and posted its best bets. Parlaying these four MLB picks today will pay more than 23-1. Head to SportsLine now to see the model's MLB picks.

Top MLB picks for Friday, August 6

The model likes the Tigers (+143) to beat the Indians at 7:10 p.m. ET. The game features two teams heading in opposite directions. Cleveland (52-54) has dropped three straight games and sits in second place in the AL Central, 9.5 games behind the division-leading White Sox. Meanwhile, Detroit (53-58) has won three of four games and is in third place in the division, 11 games behind.

The Tigers' Miguel Cabrera is riding a hot bat. Since June 14 the future Hall of Famer is hitting .314 and slugging .486 with six homers and 27 RBI. On Friday, he faces Cal Quantrill, who has given up two hits in three at-bats to Cabrera. In addition, the Indians are just 5-10 in their last 15 games at home.

How to make MLB predictions, parlays

The model has locked in three other MLB best bets, including a play on an even bigger underdog. You can see its MLB picks today only at SportsLine.

So which MLB picks should you make on Friday for a massive return of more than 23-1? And which underdog is a must-back? Visit SportsLine now to see Friday's MLB picks, all from the projection model that's off to a sizzling start in 2021, and find out.