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The Los Angeles Dodgers will try to avoid a three-game sweep when they host the Pittsburgh Pirates on Wednesday at Dodger Stadium in Los Angeles. The Dodgers (33-16) have the best record in the NL and have not been swept in any series this season, but they've dropped the first two games of this series against Pittsburgh, 6-5 and 5-3. Meanwhile, the Pirates (21-27) have clinched the season series over the Dodgers for the first time since 2016. Los Angeles is a -260 money-line favorite in the latest Dodgers vs. Pirates odds from Caesars Sportsbook, while Pittsburgh is a +220 underdog.

First pitch is set for 8:10 p.m. ET. The game is one of 16 on the MLB schedule for Wednesday. Elsewhere in the majors, Miami and Colorado collide in a doubleheader at Coors Field, and the Blue Jays look to win their seventh straight game as they take on the White Sox. Before making any MLB picks or parlays, be sure to check out the baseball predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 48-31 roll on top-rated MLB money-line picks through eight weeks, returning more than $1,100 for $100 players. Anyone following it has seen huge returns.

Now, the model has locked in four confident MLB best bets for Wednesday. If you successfully parlay the picks, you'd be looking at a payout of almost 13-1. You can only see the model's MLB picks at SportsLine. 

Top MLB picks today

The model, which simulated each of the 16 games on Wednesday's schedule 10,000 times, is taking San Francisco (+110) to defeat Philadelphia at 6:05 p.m. ET (See tickets at StubHub). The Giants (27-21) have been good on the road this season, going 14-10. Meanwhile, the Phillies (21-29) have struggled at home, going 11-15; just four NL teams have been worse at home.

San Francisco ranks fourth in the NL in slugging percentage (.407), and one of the reasons is Joc Pederson. The left-handed hitting outfielder ranks ninth in the majors in home runs (12). He also leads the team in RBI (29) and OPS (.966).

How to make Wednesday MLB parlays

The model also locked in three other best bets for Wednesday, including a play on a big American League underdog. You can find out who it is, and see the rest of the model's MLB Wednesday best bets and parlay only at SportsLine. 

What MLB picks should you parlay for a payout of almost 13-1? And what big underdog does the model like on Wednesday? Visit SportsLine now to see the MLB best bets from SportsLine's advanced model that is on a 48-31 roll on top-rated MLB money-line picks through eight weeks, and find out.