ji-man-choi-usatsi.jpg
USATSI

The New York Yankees and Boston Red Sox renew their rivalry on Friday when the two teams open a three-game series at Yankee Stadium. The Yankees (62-27) own the best record in baseball and lead the AL East by 13 games. Meanwhile, the Red Sox (47-43) are tied with the Blue Jays for third in the division as well as the third and final wild card spot. New York is a -170 favorite in the latest Yankees vs. Red Sox odds from Caesars Sportsbook while Boston is a +143 underdog.

First pitch is set for 7:05 p.m. ET from the Bronx, N.Y. The game is one of 15 on the MLB schedule for Friday. Elsewhere in the majors, the Mariners look to stretch their winning streak to 12, against the Rangers, and the Orioles try to win their 11th straight game, against the Rays. Before making any MLB picks or parlays, be sure to check out the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is 275-236 on top-rated MLB money-line picks since the start of the 2021 season, returning over $400 for $100 players. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen profitable returns.

Now, the model has locked in four confident MLB best bets for Friday. They all involve games that start after 7 p.m. ET, so there's still time to get these MLB picks in. If you successfully parlay the picks, you'd be looking at a payout of more than 13-1. You can see the model's MLB picks for Friday only at SportsLine. 

Top MLB picks today

After simulating every game on Friday 10,000 times, the model is high on San Francisco (+110) to knock off Milwaukee in the second game of a four-game series. The Brewers (50-40) have lost five of their last eight games. Meanwhile, the Giants (45-43) have won four of their last six.

In addition, Wilmer Flores is swinging a hot bat for San Francisco. Over the last seven days, the 30-year-old third baseman is hitting .375, slugging 1.000 and has an OPS of 1.400. He also has four home runs and nine RBI over that time.

How to make Friday MLB parlays

The model also locked in three other best bets for Friday, including a play on an American League underdog. You can see the model's MLB Friday best bets and parlay only at SportsLine.

What MLB picks should you target for a payout of more than 13-1? And what underdog does the model like on Friday? Visit SportsLine now to see the MLB best bets from an advanced model that is 275-236 on top-rated MLB money-line picks since the start of the 2021 season.