2022 MLB odds, picks, bets for Thursday, April 21 from proven model: This four-way parlay pays over 10-1

SportsLine's model has revealed its top MLB picks, predictions, parlay and best bets for April 21

By CBS Sports Staff

Apr 21, 2022 at 2:29 pm ET • 2 min read

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Pittsburgh got off to a surprising start this season, going 5-4 through its first nine games. The Pirates were unable to build on that momentum at Milwaukee earlier this week, getting swept in the three-game series. They will try to bounce back when they open a four-game set in Chicago against one of their National League Central rivals on Thursday night. The Cubs are listed as -160 favorites (risk $160 to win $100) in the latest MLB odds at Caesars Sportsbook.

Chicago starting pitcher Mark Leiter will be looking to bounce back after allowing seven earned runs across 3.1 innings at Colorado last weekend. Meanwhile, Pittsburgh's Bryse Wilson has given up five earned runs in his 8.1 innings on the mound. Before locking in any MLB picks or parlays, be sure to check out the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a sizzling start to the 2022 season. It's on a 14-4 roll on top-rated MLB money-line picks through two weeks, returning over $800 for $100 players. Anyone following it has seen huge returns.

Now, the model has locked in four confident MLB best bets for Thursday. They all involve games at 4:05 p.m. ET or later, so there's still time to get these MLB picks in. If you successfully parlay the picks, you'd be looking at a payout of more than 10-1. You can see the model's MLB picks for Thursday only at SportsLine.

Top MLB picks today

After simulating each of Thursday's games 10,000 times, the model likes Seattle, a -130 favorite, to beat Texas. The Mariners have dominated this series of late, winning 18 of their last 20 meetings at home against Texas. They have also won seven straight games overall in the series, including both games earlier this week. Texas starter Taylor Hearn allowed three runs on six hits across just 3.2 innings in his last start.

Hearn has struggled against Seattle in his career, going 0-3 with a 6.20 ERA in 12 appearances. Left-hander Marco Gonzales, who allowed just one run on four hits over seven innings in his last start, is going to be on the bump for the Mariners. Gonzales is 8-6 with a 3.73 ERA against Texas during his career, which is one reason why SportsLine's model has Seattle winning almost 60 percent of the time.