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The Baltimore Orioles, who have the second-best record in Major League Baseball, will look to stay hot when they take on the Chicago Cubs in an interleague matchup on Friday afternoon. The Orioles (43-25), who are 8-6 in interleague games, are 26-17 against right-handed starters. The Cubs (31-37), who are 10-11 in interleague play, are 11-9 against left-handed starters. Baltimore is 21-12 away from home in 2023, while Chicago is 18-16 at home.

The game from Wrigley Field in Chicago is slated to begin at 2:20 p.m. ET. Chicago is the -130 favorite (risk $130 to win $100) in the latest Orioles vs. Cubs odds from Caesars Sportsbook, while the over/under for total runs scored is 8. Before making any Cubs vs. Orioles picks, be sure to check out the latest MLB predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It went 331-285 on top-rated MLB money-line picks (+357) over the past two seasons. It has opened the 2023 MLB season on a 33-25 roll on all-top rated MLB picks. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on Orioles vs. Cubs and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Here are several MLB betting lines and trends for Cubs vs. Orioles:

  • Orioles vs. Cubs money line: Cubs -130, Orioles +110
  • Orioles vs. Cubs over/under: 8 runs
  • Orioles vs. Cubs run line: Cubs -1.5 (+170)
  • BAL: The Orioles are 4-1 in their last five interleague games against a team with a losing record
  • CHI: The Cubs are 8-2 in their last 10 games vs. a team with a winning % above .600
  • Orioles vs. Cubs picks: See picks at SportsLine

Why you should back the Orioles

Baltimore is expected to send left-hander Cole Irvin (1-2, 7.85 ERA) to the mound. He'll be backed by an offense that has scored the seventh most runs in the league. Third baseman Ramon Urias has played well since returning from injury, and has three multi-hit games over his past six games. In an 11-3 win over Kansas City on Sunday, Urius was 4-for-5 with two doubles, two RBI and two runs scored. He was 3-for-4 with a double, homer and RBI in a 6-3 win at Milwaukee on June 8. For the season, Urius is hitting .272 with two homers, 20 RBI and 19 runs scored.

Shortstop Jorge Mateo gives the Orioles speed on the base paths. In Thursday's win over Toronto, Mateo was 2-for-4 with a pair of stolen bases. The fourth-year veteran has 18 steals on the year and is coming off a 2022 season which saw him swipe 35 bags. In 59 games this season, Mateo is hitting .234 with six homers, 25 RBI and 34 runs scored. See which team to back here.

Why you should back the Cubs

Right-hander Kyle Hendricks (1-2, 3.09 ERA) will get the start for Chicago. Hendricks, who is in his 10th year with the Cubs, is coming off a dominant performance in Saturday's 4-0 victory over the San Francisco Giants. In eight innings of work, he allowed just one hit and one walk, while striking out three. His no-hit bid ended in the eighth. In 227 career games, including 226 starts, Hendricks is 88-63 with a 3.45 ERA.

Right fielder Seiya Suzuki has been on fire, registering three multi-hit games in his last five appearances. Entering play on Thursday, he was batting .282 with six homers, 21 RBI and 25 runs scored. In a 3-2 win over the Giants on June 9, he was 3-for-3 with a double and a walk. In two career games against Baltimore, he is hitting .250 with a stolen base. See which team to back here.

How to make Cubs vs. Orioles picks

SportsLine's model is leaning Over on the total, projecting 10.5 combined runs. It also says one side of the money line has all of the value. You can only get the model's MLB picks at SportsLine.

So who wins Orioles vs. Cubs, and which side has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has gone 33-25 on its top-rated MLB picks, and find out.