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Robert Hanashiro / USA TODAY Sports

The Cleveland Indians look for the series sweep when they take on the visiting Minnesota Twins in a key American League Central Division matchup on Wednesday. The Indians (11-11), third in the division, have won three consecutive games. The Twins (7-15), fourth in the Central, have dropped four in a row. Minnesota has won seven of the last 11 meetings against Cleveland.

First pitch from Progressive Field in Cleveland is set for 1:10 p.m. ET. The Indians lead the all-time series 1,164-1,022, including a 637-457 edge in games played at Cleveland. Minnesota is the -115 favorite on the money line in the latest Twins vs. Indians odds from William Hill Sportsbook, while the over-under for total runs scored is 9. Before making any Indians vs. Twins picks, check out the latest MLB predictions and betting advice from the SportsLine Projection Model.

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line MLB picks. It is off to a profitable start in 2021, going 29-21 on top-rated MLB money-line picks through four weeks, returning over $250. Anyone following it has seen huge rewards. 

Now, the model has dialed in on Twins vs. Indians. You can visit SportsLine now to see the picks. Here are the MLB lines and trends for Indians vs. Twins:

  • Twins vs. Indians money line: Minnesota -115, Cleveland +105
  • Twins vs. Indians run line: Twins -1.5
  • Twins vs. Indians over-under: 9 runs
  • MIN: The Twins are 14-6 in their last 20 vs. AL Central teams
  • CLE: The Indians are 44-17 in their last 61 games vs. a team with a winning percentage below .400

Why you should back the Twins

Minnesota will send left-handed pitcher J.A. Happ (1-0, 1.69 ERA) to the mound. Happ was nearly unhittable on Friday when he fell just five outs shy of his first career no-hitter. That was his first outing of his 15-year MLB career going longer than seven innings and allowing just one hit. In seven career games against the Indians, Happ has six starts, going 3-2 in 34 1/3 innings, allowing 38 hits, 16 earned runs, three homers and 10 walks with 28 strikeouts for a 4.19 ERA.

Right fielder Nelson Cruz has been red-hot of late, with hits in five of his last six games, including a three-game hitting streak. On Tuesday, Cruz was 2-for-4 with a triple, two runs scored and an RBI. For the season, he is hitting .329 with seven home runs and 16 RBIs. In 97 career games against Cleveland, Cruz is hitting just .238, but has 26 homers and 51 RBIs.

Why you should back the Indians 

Cleveland left-hander Logan Allen (1-3, 6.28 ERA) will take the hill as he looks to turn around his fortunes. In his last outing, he allowed four runs on five hits in 2 1/3 innings. His best outing was April 11 against Detroit. In that game, he allowed just two hits, one earned run, while walking three and striking out five in five innings for his only victory. This will be his first appearance against the Twins.

Offensively, right fielder Franmil Reyes has raised his batting average 74 points over the last eight games, going 14-for-35 (.400) over that span. He is 7-for-12 over the past three games, including a pair of 3-for-4 performances. On Tuesday, Reyes was 3-for-4 with two home runs. In 22 career games against Minnesota, Reyes has 17 hits, including three doubles, two homers and eight RBIs.

How to make Indians vs. Twins picks

SportsLine's model is leaning under on the total, as the teams combine for 8.2 runs in the simulations, and it also says one side of the money line has all the value. You can only see the pick at SportsLine. 

So who wins Twins vs. Indians? And which side of the money line has all the value? Visit SportsLine now to see which side of the money line to jump on, all from the advanced model that returned more than $1,400 in 2019.