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We've got another exciting Atlantic Division matchup on the NBA schedule as the Boston Celtics and the Philadelphia 76ers are set to tip at 7 p.m. ET on Wednesday at the Wells Fargo Center in Philadelphia. The Sixers are 5-1 overall and 4-0 at home, while Boston is 5-1 overall and 3-1 on the road. The Celtics are 2-2-2 against the spread on the season while Philadelphia is a perfect 6-0 against the number.

However, the Celtics have won six of the last 10 head-to-head matchups and are 7-3 against the spread during that span. This time around, Boston is favored by 2 points in the latest 76ers vs. Celtics odds, and the over/under is 227.5 points. Before entering any Celtics vs. 76ers picks, you'll want to see the NBA predictions from the model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past five-plus seasons. The model enters Week 3 of the 2023-24 NBA season on a 79-42 roll on all top-rated NBA picks dating back to last season, returning more than $3,000. Anyone following it has seen huge returns.

The model has set its sights on Sixers vs. Celtics. You can head to SportsLine to see its picks. Here are several NBA odds and betting lines for Celtics vs. Sixers:

  • 76ers vs. Celtics spread: 76ers +2
  • 76ers vs. Celtics over/under: 227.5 points
  • 76ers vs. Celtics money line: 76ers: +114, Celtics: -137
  • 76ers vs. Celtics picks: See picks here

What you need to know about the Celtics

The Celtics unfortunately witnessed the end of their five-game winning streak on Monday. They took a 114-109 loss at the hands of Minnesota despite being 3-point road favorites. It was a tough shooting night for the Celtics, as they went just 11-for-39 from the 3-point line and shot just 39.1% from the floor.

Despite the defeat, Jayson Tatum had 32 points along with five steals. The contest was Tatum's fourth in a row with at least 30 points, but he's only had one 30-point game in 21 regular-season battles with the Sixers. The four-time NBA All-Star is averaging 30.5 points, 8.8 rebounds and 3.2 assists per game this season.

What you need to know about the 76ers

Meanwhile, Philadelphia strolled past Washington on Monday, taking the game 146-128. The Sixers shot a staggering 56% from the floor in the victory and forced the Wizards into 19 turnovers. With that win, the 76ers brought their scoring average up to 121.5 points per game for the season.

Joel Embiid continued his habit of posting crazy stat lines, dropping a double-double on 48 points and 11 rebounds. He's now pulled down 10 or more rebounds in the last four games he's played. The team also got some help courtesy of Tyrese Maxey, who dropped a double-double on 22 points and 11 assists.

How to make 76ers vs. Celtics picks

The model has simulated 76ers vs. Celtics 10,000 times and the results are in. We can tell you that the model is leaning Under and it's also generated a point-spread pick where one side hits almost 60% of the time. You can only see the pick at SportsLine.

Who wins Celtics vs. 76ers, and which side of the spread hits almost 60% of the time? Visit SportsLine now to see the picks, all from the model that finished last year on a 79-42 roll on top-rated NBA picks, and find out.