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A cross-conference matchup features the San Antonio Spurs hosting Jayson Tatum and the Boston Celtics on Saturday afternoon. The Spurs are currently 13-26 on the year, while Boston owns a 27-12 overall record. This will be the first of two matchups on the season between these teams. San Antonio leads the all-time series 58-41, including a two-game win streak over Boston. San Antonio has injury concerns surrounding its top two scorers with Devin Vassell (knee) out indefinitely and Keldon Johnson (hamstring) considered day-to-day. 

Tipoff is scheduled for 6 p.m. ET at the AT&T Center in San Antonio. Caesars Sportsbook lists Boston as the 14-point favorite in the latest Celtics vs. Spurs odds. The over/under for total points is set at 234.5. Before locking in any Spurs vs. Celtics picks, you need to see the NBA predictions and betting advice from SportsLine's advanced computer simulation model.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past four-plus seasons. The model enters Week 12 of the 2022-23 NBA season on a stunning 38-13 roll on all top-rated NBA picks this season, returning almost $2,300. Anyone following it has seen huge returns.

Now, the model has set its sights on Celtics vs. Spurs and just locked in its picks and NBA predictions. You can head to SportsLine now to see the model's picks. Now, here are several NBA odds and betting lines for Spurs vs. Celtics:

  • Celtics vs. Spurs spread: Boston -14
  • Celtics vs. Spurs over/under: 234.5 points
  • Celtics vs. Spurs money line: Boston -1000, San Antonio +650
  • BOS: Celtics are 8-3 ATS in their last 11 games following an ATS win
  • SA: Spurs are 4-0 ATS in their last four home games
  • Celtics vs. Spurs picks: See picks at SportsLine

Why the Celtics can cover

Guard Jaylen Brown is an explosive and dynamic athlete. Brown has the bounce and strength to rise over defenders and finish with force. The California product likes to attack downhill but owns a steady jumper across the court. The 26-year-old averages 26.9 points and 7.1 rebounds per game. On Jan. 1, Brown dropped 30 points and eight rebounds.

Guard Malcolm Brogdon has been an outstanding two-way presence off the bench. Brogdon knows the right play to make both offensively and defensively due to his great awareness. The Virginia product is able to get a bucket at all three levels. Brogdon logs 13.2 points, 4.1 rebounds and 3.8 assists per contest. He had 15 points, four assists and knocked down three 3-pointers in his last game. 

Why the Spurs can cover

Center Jakob Poeltl provides San Antonio with a two-way threat in the frontcourt. Poeltl is a superb defender near the rim due to his awareness and length. The Utah product owns a soft touch in the restricted area and has become a solid passer. Poeltl is averaging 11.9 points, 9.5 rebounds, and shoots 64% from the field. In his previous game, he finished with 11 points, 16 rebounds, seven assists and three blocks.

Guard Tre Jones is an excellent ball handler who owns a nice jumper from the perimeter. Jones scans the floor well and will deliver strikes to his teammates. The Duke product is fearless on both ends of the floor. Jones puts up 13.1 points, 6.4 assists and 1.4 steals per game. On Jan. 6, he logged 25 points, three assists and two steals. 

How to make Spurs vs. Celtics picks

SportsLine's model is leaning Over on the total, projecting 235 combined points. The model also says one side of the spread hits in almost 60% of simulations. You can only see the model's pick at SportsLine.

So who wins Celtics vs. Spurs? And which side of the spread hits in almost 60% of simulations? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has crushed its NBA picks, and find out.