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The Pittsburgh Steelers will try to rebound from their worst loss in 33 years when they host the Tampa Bay Buccaneers in an interconference matchup on Sunday. The Steelers (1-4), who have lost four in a row, were beaten 38-3 at Buffalo last week. It was the team's worst loss since suffering a 51-0 setback to the Cleveland Browns in 1989. The Buccaneers (3-2), meanwhile, snapped a two-game losing streak when they defeated the Atlanta Falcons 21-15 in Week 5.

Kickoff from Acrisure Stadium in Pittsburgh is set for 1 p.m. ET. Tampa Bay is a 9.5-point favorite in the latest Buccaneers vs. Steelers odds from Caesars Sportsbook, while the over/under for total points scored is 46. Before making any Steelers vs. Buccaneers picks, you need to check out the NFL predictions and betting advice from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 6 of the 2022 NFL season on an incredible 146-106 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Buccaneers vs. Steelers, and just locked in its picks and NFL predictions. You can visit SportsLine now to see the model's picks. Here are the NFL odds and betting lines for Steelers vs. Buccaneers:

  • Buccaneers vs. Steelers spread: Buccaneers -9.5
  • Buccaneers vs. Steelers over/under: 46 points
  • Buccaneers vs. Steelers money line: Buccaneers -480, Steelers +360
  • TB: Buccaneers are 5-1 against the spread in their last six road games
  • PIT: Steelers have failed to cover three straight games
  • Buccaneers vs. Steelers picks: See picks at SportsLine

Why the Buccaneers can cover

Quarterback Tom Brady continues to build his resume for his induction into the Pro Football Hall of Fame. Last week, he passed for 351 yards and a touchdown with no interceptions for a 92.7 rating. He has 56 career games with 350 or more passing yards, second-most all-time, and will be looking for his third game in a row with 350-plus passing yards. He has 3,744 passing yards (312 per game) and 30 touchdowns with five interceptions for a 111.1 rating in 12 career regular-season starts against Pittsburgh.

Also off to a solid start to the season is running back Leonard Fournette. In five games this season, Fournette has carried 74 times for 280 yards (3.8 average) and one touchdown. He also has a team-leading 26 receptions for 194 yards (7.5 average) with two touchdowns and two explosive plays of 20 yards or more. In last week's win over Atlanta, he rushed 14 times for 56 yards and a score and also caught 10 passes for 83 yards and a TD.

Why the Steelers can cover 

Rookie quarterback Kenny Pickett gets his second career start. He played admirably in the Steelers' loss to the Bills last Sunday. He completed 34 of 52 passes (65.4 percent) for 327 yards with one interception and a rating of 74.8. A week earlier, he came in in relief of Mitch Trubisky and completed 10 of 13 passes (76.9 percent) for 120 yards and three interceptions in a 24-20 loss to the New York Jets.

Wide receiver Diontae Johnson leads the Steelers with 28 receptions for 267 yards (9.5 average) with two explosive plays, including a long of 25 yards. He has also converted 14 first downs. Johnson has five or more catches and 50-plus receiving yards in four games this season, tied for the most in the NFL. He has five or more catches in 16 of his past 17 games and has 70-plus scrimmage yards in seven of his past eight games against NFC opponents.

How to make Buccaneers vs. Steelers picks

SportsLine's model is leaning Under on the point total. In fact, it's calling for 43 total points. It also says one side of the spread cashes in well over 50% of simulations. You can only see the model's pick at SportsLine. 

So who wins Steelers vs. Buccaneers? And which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the Buccaneers vs. Steelers spread to jump on, all from the advanced model that is up almost $7,000 on NFL picks, and find out.