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The NFC West lead will be on the line when the Los Angeles Rams battle the Seattle Seahawks in a matchup of two of the best teams in the NFL on 'Thursday Night Football.' Los Angeles is coming off a 41-34 win over the Detroit Lions, while Seattle squeaked past the Indianapolis Colts on Sunday. The Rams (11-3), who have won two in a row, are 5-2 on the road this season. The Seahawks (11-3), who have won four consecutive games, are 5-2 on their home field. Rams wide receiver Davante Adams (hamstring) is expected to miss this game.

Kickoff from Lumen Field in Seattle is set for 8:15 p.m. ET. The all-time series is tied 28-28, with Los Angeles earning a 21-19 win in their last meeting in November. The Rams are 1-point favorites in the latest Rams vs. Seahawks odds, while the over/under for total points scored is 44 via DraftKings Sportsbook. Before making any Rams vs. Seahawks picks, check out the NFL predictions from the SportsLine Projection Model. 

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 16 on a 52-37 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, the model has set its sights on Rams vs. Seahawks. You can visit SportsLine now to see the picks. Here are the FBS college football odds and trends for Seahawks vs. Rams:

Rams vs. Seahawks spread

Los Angeles -1 at DraftKings Sportsbook

Rams vs. Seahawks over/under

44 points

Rams vs. Seahawks money line 

Los Angeles -110, Seattle -108

Rams vs. Seahawks picks

See picks at SportsLine

Rams vs. Seahawks streaming 

Prime Video

Why the Rams can cover

Los Angeles is powered by MVP candidate Matthew Stafford. The veteran quarterback has played in 14 games and completed 66.4% of his passes for 3,722 yards and 37 touchdowns with just five interceptions and a 112.2 rating. In the win over the Lions on Sunday, he completed 24 of 38 passes for 368 yards and two touchdowns with one interception. He completed 22 of 31 passes for 281 yards and three touchdowns in a 45-17 win over the Arizona Cardinals on Dec. 7.

Wide receiver Puka Nacua is among the Rams' top weapons. In 13 games, he has 102 receptions for 1,367 yards (13.4 average) and six touchdowns. He has had 23 explosive plays of 20 yards or more, including a long of 39, with 487 yards after the catch and 66 first-down conversions. He has also rushed eight times for 81 yards and a score. See which team to back at SportsLine. 

Why the Seahawks can cover

Eighth-year veteran quarterback Sam Darnold leads the Seattle offense. In 14 games, he has completed 67.4% of his passes for 3,433 yards and 22 touchdowns with 11 interceptions and a rating of 102. In Sunday's win over the Colts, he completed 22 of 36 passes for 271 yards, including a long of 39. He completed 20 of 30 passes for 249 yards and three touchdowns with one interception in a 37-9 win at Atlanta on Dec. 7.

His top target is third-year wide receiver Jaxon Smith-Njigba. In 14 games, he has 96 receptions for 1,541 yards and nine touchdowns. He has 25 explosive plays of 20 or more yards, including a long of 63 yards, with 454 yards after the catch and 66 first-down conversions. In the win over Atlanta, he caught seven passes for 92 yards and two touchdowns. See which team to back at SportsLine.

How to make Rams vs. Seahawks picks

SportsLine's model is going Over on the total, projecting 45 combined points. It also says one side of the spread is the better value. You can only get the pick at SportsLine. 

So who wins Seahawks vs. Rams, and which side of the spread is the better value? Visit SportsLine now to see which side of the Rams vs. Seahawks spread to jump on, all from the advanced model that finished up over $7,000 on its NFL picks since its inception, and find out.