Steelers quarterback Ben Roethlisberger will play what could be his final NFL game when the Pittsburgh Steelers face the Baltimore Ravens in the teams' regular season finale on Sunday. The 39-year-old Roethlisberger, who has won two Super Bowls, has said that this season will be his last. In order for his season to continue beyond Sunday, the Steelers (8-7-1) need a win over the Ravens (8-8), a Colts (9-7) loss to the Jaguars (2-14), and Raiders vs. Chargers not to end in a tie. Baltimore is a five-point favorite in the latest NFL odds from Caesars Sportsbook.

The game is one of 16 on a loaded Week 18 NFL schedule. Other key NFL matchups include the Chargers and Raiders facing off on Sunday Night Football and the Rams and 49ers battling in a game with postseason implications. Before making any Week 18 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up over $7,200 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 18 of the 2021 season on an incredible 135-96 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 18. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 18 NFL picks at SportsLine. 

Top Week 18 NFL picks

After simulating every game 10,000 times, the model is high on the Buccaneers to cover as eight-point favorites at home against the Carolina Panthers. Tampa Bay (12-4) is coming off a 28-24 win at the Jets in which the team had to rally from a 14-point second-half deficit. Carolina (5-11) is coming off an 18-10 loss to New Orleans.

Buccaneers quarterback Tom Brady is having another standout season. The seven-time Super Bowl winner needs just 16 completions on Sunday to set the single-season NFL record. Drew Brees currently owns the record, with 471 set in 2016. Brady also needs just 10 passing yards to become just the second player in league history with multiple 5,000-yard passing seasons (joining Brees).

How to make Week 18 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including an underdog that wins outright. You can only see the model's NFL Week 18 best bets and parlay at SportsLine. 

What are the model's top Week 18 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 18 NFL best bets from a model on a 135-96 run on its top-rated picks, and find out.