Week 4 NFL betting guide, props, spreads: Model, expert, parlay, DFS and season-long fantasy picks revealed
SportsLine's team of Vegas experts and its proven model and experts to get you ready for Week 4 NFL betting
Last season, there were five games with NFL spreads of at least two touchdowns, and all five games took place in December. Thus, Buffalo being a 14.5-point favorite over New Orleans, per the Week 4 NFL odds, comes at an interesting time, but it says lots about both teams. The Saints are one of three winless teams against the spread, along with Denver and Houston. Despite that, the Week 4 NFL odds have both the Broncos and Texans as touchdown favorites in their respective games as there are four Week 4 NFL lines of 7 points or more.
A Week 4 NFL betting guide would help navigate the final slate of games before the byes hit and also help identify the top players to target for NFL props, Week 4 Fantasy football lineups and as NFL DFS picks. Will players like Josh Allen, James Cook, Bo Nix, Courtland Sutton and C.J. Stroud help justify their teams being heavy favorites? Which NFL expert picks can you lean on for spread betting or straight-up predictions?
If you are looking for NFL picks, NFL parlays, Fantasy football rankings or NFL DFS picks for Week 4, SportsLine has you covered with its proven model, Machine Learning Model and team of experts.
NFL parlay picks could generate massive payouts
SportsLine's model has returned well over $7,000 on top-rated NFL betting picks since its inception, so those picks can confidently be used to fill out NFL parlay picks on betting apps. The model has built a five-team parlay for Week 4 that pays 25-1, and one of the legs is the Houston Texans (-7, 39.5) covering against the Tennessee Titans at home. The model has Houston covering in well over 50% of simulations, and the rest of the five-team parlay can be found here.
Fantasy rankings to help you win your matchups
SportsLine's model simulates every game 10,000 times, which has helped it produce better Fantasy rankings than human experts over the last few seasons. It has revealed its Week 4 Fantasy football rankings that can be used to make start-sit decisions. New England's Drake Maye is projected to be a top-5 Fantasy quarterback this week, and the model also has full rankings for every position right here.
NFL DFS picks from top experts
SportsLine has a DFS Optimizer that simulates every game 10,000 times and uses info from the SportsLine Projection Model and DFS Professional Millionaire Mike McClure to identify top DFS picks/plays for any slate on sites like FanDuel and DraftKings. It has Chicago's Caleb Williams as one of its top value picks at quarterback, while San Francisco's Ricky Pearsall is among the best values at receiver for Sunday's main slate. Here are its complete Week 4 NFL DFS rankings.
Senior Fantasy Writer Heath Cummings has locked in his projections for every Fantasy relevant quarterback, running back, wide receiver and tight end in your leagues. Not only do you get statistical projections as well as Fantasy point totals for every player in different scoring formats, but Cummings also includes DFS prices and values to help build winning DFS lineups each week. Get his Week 4 Fantasy and DFS projections right here. You can also make NFL prop bets on Williams, Pearsall and others with the Underdog Fantasy promo code CBSSPORTS2.
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Advanced NFL model simulates every game 10,000 times
SportsLine's model enters Week 4 of the 2025 NFL season up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 39-19 run on top-rated picks dating back to 2024 and has revealed picks for every Week 4 NFL game. One of its favorite picks is the Bears (+1.5) covering on the road versus the Raiders, which cashes almost 60% of the time. You can find the model's picks for every NFL Week 4 game here.
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NFL Vegas expert picks revealed
SportsLine has an expansive team of NFL experts who provide quality betting advice for every game on the schedule. Analyst Mike Tierney, who is on an 8-2 roll (+581) over his last 10 NFL picks, has revealed his best bets for Week 4. He is backing the Chargers (-6.5) to cover on the road versus the Giants in Jaxson Dart's first start. Tierney's NFL best bets for Week 4 can be found here.
Eric Cohen, who is 35-13 (73%) on his straight-up NFL picks this season, has exact score predictions for all 16 games. He is high on the Eagles (-3.5, 44.5) to defeat the Bucs, 24-20, on Sunday. Hit any of his exact score picks and you're looking at a payout well over 100-1. That pick, along with his prediction for every game, is available here.
Cowboys vs. Packers Sunday Night Football picks
A storied rivalry will resume on Sunday Night Football as Micah Parsons makes a return to Dallas as his Packers will take on the Cowboys. Green Bay has defeated Dallas in five straight games, including two postseason contests, and scored at least 31 points in each game. SportsLine's model likes the Packers (-6.5) to cover, projecting they win versus the spread in over 50% of simulations. NFL expert R.J. White, who is 77-32-22 (+3969) on his last 131 side picks in Packers games, has analyzed this matchup from every angle and locked in his best bets for SNF right here.
SportsLine's Machine Learning Model AI has locked in its player props for stars like Dak Prescott, Jordan Love and Josh Jacobs. One of its top picks is Prescott going Over 238.5 passing yards, which has a 4.5-star rating. The Machine Learning Model is calling for Prescott to have 286.2 yards on average. You can see all the top-rated NFL props from the SportsLine Machine Learning Model here.
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Jets vs. Dolphins Monday Night Football picks
A team will, presumably, get its first win in the opener of a two-game MNF slate as the Dolphins host the Jets. New York has lost nine straight visits to Miami, but the Dolphins have lost seven of their last eight primetime games. SportsLine's model likes the Dolphins (-2.5) to cover in almost 60% of simulations. NFL expert Emory Hunt, who is 18-9 (+805) over his last 27 picks in Jets games, has analyzed this matchup from every angle and locked in his best bets for MNF right here.
Bengals vs. Broncos Monday Night Football picks
The second MNF contest sees a pair of AFC hopefuls locking up as the Bengals visit the Broncos (-7.5). Cincy has won four of its last five road games -- and also beat the Broncos at home last December -- while Denver is riding a six-game home winning streak. SportsLine's model likes the Over (44) to hit well over 60% of the time as it predicts 52 combined points. It has also revealed its picks on the spread and money line. SportsLine's Model has also locked in its player projections for the likes of Bo Nix, J.K. Dobbins and Ja'Marr Chase. You can see all the NFL player projections from the SportsLine Model here.
