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An ACC battle is on tap between the Syracuse Orange and the Notre Dame Fighting Irish at 7 p.m. ET Wednesday at Purcell Pavilion at the Joyce Center. Notre Dame is 19-8 overall and 11-1 at home, while 'Cuse is 15-12 overall and 3-6 on the road. Syracuse has won seven of the last 10 head-to-head meetings between the teams.

The Fighting Irish are favored by five points in the latest Notre Dame vs. Syracuse odds from Caesars Sportsbook, and the over-under is set at 145.5. Before entering any Syracuse vs. Notre Dame picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,000 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Notre Dame vs. Syracuse. You can head to SportsLine to see its picks. Here are several college basketball odds for Syracuse vs. Notre Dame:

  • Notre Dame vs. Syracuse spread: Notre Dame -5
  • Notre Dame vs. Syracuse over-under: 145.5 points

What you need to know about Notre Dame

The Fighting Irish were within striking distance but couldn't close the gap this past Saturday as they fell 79-74 to the Wake Forest Demon Deacons. The loss ended a five-game winning streak for the Irish. A silver lining for Notre Dame was the play of guard Blake Wesley, who shot 6-for-11 from beyond the arc and finished with 24 points.

The Irish are paced by three double-digit scorers, led by Wesley at 14.7 points per game and Dane Goodwin at 14.6 PPG. Forward Paul Atkinson is third on the team with 12.3 PPG while also leading Notre Dame in both rebounds (6.9) and blocks (0.6). Atkinson has 17 of the Irish's 53 blocks this season and their 2.0 blocks per game ranks 335th out of 358 Division I teams.

What you need to know about Syracuse

Meanwhile, Syracuse escaped with a win on Monday against the Georgia Tech Yellow Jackets by the margin of a single free throw, 74-73. Four players on 'Cuse scored in the double digits: forward Jimmy Boeheim (20), forward Cole Swider (18), guard Buddy Boeheim (15), and guard Joseph Girard III (12).

Both Jimmy Boeheim and Swider had double-doubles in the game with 10 and 12 rebounds, respectively. Center Frank Anselem also crashed the boards and pulled down 10 rebounds to go along with two blocked shots. The Orange do a great job of attacking the glass and preventing opponent rebounds as they give up the second-fewest rebounds in the ACC at 36.8 per game.

Notre Dame vs. Syracuse picks

The model has simulated Notre Dame vs. Syracuse 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Syracuse vs. Notre Dame? And which side of the spread hits well over 50 percent of the time? Visit SportsLine now to see which side of the spread to jump on, all from the advanced model that is up almost $2,000 on its college basketball picks the last five-plus years, and find out.