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The No. 6 Houston Cougars and the SMU Mustangs are set to square off in an American Athletic matchup at 7 p.m. ET on Wednesday at Moody Coliseum. SMU is 16-5 overall and 11-0 at home, while the Cougars are 20-2 overall and 5-1 on the road. The Cougars have opened up a two-game lead atop the AAC standings after SMU lost on Saturday.

Houston is 14-8 against the spread so far this season while SMU is 10-11. The Cougars are favored by seven points in the latest SMU vs. Houston odds from Caesars Sportsbook, and the over-under is set at 135. Before entering any Houston vs. SMU picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $2,300 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on SMU vs. Houston. You can head to SportsLine to see its picks. Here are several college basketball odds for Houston vs. SMU:

  • SMU vs. Houston spread: SMU +7
  • SMU vs. Houston over-under: 135 points

What you need to know about SMU

The contest between SMU and the Wichita State Shockers this past Saturday was not a total blowout, but with SMU falling 72-57 on the road, it was darn close to turning into one. Forward Marcus Weathers (14 points) and guard Emmanuel Bandoumel (12 points) were the top scorers for SMU.

SMU shot just 36.5 percent from the floor in the loss and went just 5-for-20 from the 3-point line while committing 17 turnovers. The loss snapped a five-game winning streak and now it's got to make up two games on Houston to win the AAC regular-season title.

What you need to know about Houston

Meanwhile, everything went Houston's way against the Cincinnati Bearcats on Sunday as it made off with an 80-58 victory. Forward Fabian White Jr. was the offensive standout of the matchup for the Cougars, picking up 22 points along with nine boards. Jamal Shead also had a solid day with 17 points and six assists.

It was an efficient offensive performance for Houston, who shot 53.3 percent from the floor. At the other end of the floor, the Cougars held the Bearcats to just 34.0 percent shooting from the floor and 20.0 percent shooting from the 3-point line. Houston has now won 12 games in a row and is unbeaten in conference play so far this season.

How to make Houston vs. SMU picks

The model has simulated SMU vs. Houston 10,000 times and the results are in. We can tell you that the model is leaning over and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins SMU vs. Houston? And which side of the spread hits over 50 percent of the time? Visit SportsLine now to find out, all from the model that has crushed its college basketball picks.