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The St. John's Red Storm and the Villanova Wildcats are set to square off in a Big East matchup at 6:30 p.m. ET on Wednesday at Finneran Pavilion. Villanova is 6-5 overall and 4-0 at home, while the Red Storm are 11-1 overall and 0-1 on the road. Villanova leads the all-time series with 56 wins versus 48 losses, and it has also won each of the last four meetings.

The Wildcats are favored by 5 points in the latest Villanova vs. St. John's odds from Caesars Sportsbook, and the over/under is set at 146. Before entering any St. John's vs. Villanova picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. The model enters Week 7 of the 2022-23 college basketball season on a strong 19-12 roll on all-top rated CBB picks, returning more than $200. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on Villanova vs. St. John's. You can head to SportsLine to see its picks. Here are several college basketball odds for St. John's vs. Villanova:

  • Villanova vs. St. John's spread: Villanova -5
  • Villanova vs. St. John's over/under: 146 points
  • Villanova vs. St. John's money line: Villanova -210, St. John's +175
  • Villanova vs. St. John's picks: See picks here

What you need to know about Villanova

Villanova was able to grind out a solid win over the Saint Joseph's Hawks this past Saturday, winning 71-64. Villanova can attribute much of its success to forward Brandon Slater, who shot 5-for-8 from beyond the arc and finished with 19 points and eight boards, and guard Chris Arcidiacono, who had 14 points.

After having a top-20 offense in last season's run to the Final Four, Villanova ranks just 65th in offensive rating this year. But the team has received a boost with the debut of freshman Cam Whitmore (13.5 points per game) four games ago. Whitmore recovered from thumb surgery to make his debut on Dec. 3, and the Wildcats have won all four of their games since. 

What you need to know about St. John's

Meanwhile, St. John's didn't have too much trouble with the Florida State Seminoles this past Saturday as it won 93-79. St. John's center Joel Soriano did his thing and posted a double-double on 23 points and 12 rebounds.

St. John's has balanced scoring as all five starters average at least 9.8 PPG. Soriano has been a huge presence in the paint, averaging 15.2 PPG and a Big East-leading 12.6 rebounds per game. DePaul transfer David Jones is chipping in with 15.1 points and 7.4 rebounds, while former Big Ten Sixth Man of the Year, and Illinois transfer, Andre Curbelo is averaging 11.3 PPG and a team-high of 4.9 assists.

How to make Villanova vs. St. John's picks

The model has simulated Villanova vs. St. John's 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the pick at SportsLine.

So who wins St. John's vs. Villanova? And which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has crushed its college basketball picks, and find out.