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A trip to the national championship is on the line when the College Football Playoff semifinals continue on Friday. The No. 1 Indiana Hoosiers take on the No. 5 Oregon Ducks at 7:30 p.m. ET in a Big Ten battle, with the winner advancing to take on Miami. The Hoosiers won the first meeting of the season, 30-20, and Indiana is favored by 3.5 points this time around. The over/under for Indiana vs. Oregon is 48.5 points, up two from the opening line. Before locking in your College Football Playoff semifinal picks, be sure to check out the top college football betting picks from SportsLine's advanced computer model. 

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The model simulates every FBS game 10,000 times, and it is 31-19 on its top-rated college football money-line picks since the beginning of the 2024 season. Anybody following those college football betting picks at sportsbooks and on betting sites could have seen strong returns.

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College football best bets for CFP semifinals (odds subject to change): 

  • Oregon (+3.5) vs. Indiana
  • Oregon vs. Indiana: Under 48.5 points

Bet it now at Caesars Sportsbook: 

Oregon (+3.5) vs. Indiana

Both defenses were disruptive in the quarterfinals, with Oregon posting a shutout against Texas Tech and Indiana holding Alabama to just three points. These two foes squared off on Oct. 11, with Indiana walking away with a 30-20 victory on the road. Oregon has reeled off eight consecutive wins since then, and the Ducks are 4-1 against the spread in their last five games. According to the model's projections, Oregon suffers a 24-22 defeat, but the Ducks cover the spread 54% of the time. Bet on Oregon vs. Indiana at FanDuel Sportsbook, where new users can bet $5, get $300 in bonus bets if your bet wins. 

Indiana vs. Oregon: Under 48.5 points

Both of these defenses have been playing spectacularly in recent weeks. Oregon has given up 16 or fewer points in six of its past eight games, which includes shutting out Texas Tech in the quarterfinals, while Indiana has conceded 10 points or fewer in six of its last seven contests. These two teams combined to go 8/28 on 3rd-down conversions in the first meeting, and SportsLine's model is projecting another defensive battle as these teams combine for 46 points on Friday, helping the Under hit in 59% of simulations. Bet on Indiana vs. Oregon at bet365, where new users can get $200 in bonus bets after placing a first wager of $5 or more.

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