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South Alabama will be looking to build off its 48-7 win over Nicholls State when it travels to Central Michigan on Saturday afternoon. The Jaguars held Nicholls to 165 total yards and fewer than 20 yards in the fourth quarter. Central Michigan is coming off a 58-44 loss to No. 12 Oklahoma State in its season opener.

Kickoff is set for 1 p.m. ET. The Chippewas are 6-point favorites in the latest Central Michigan vs. South Alabama odds from Caesars Sportsbook, while the over/under for total points scored is 57.5. Before entering any South Alabama vs. Central Michigan picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It enters Week 2 of the 2022 college football season on a 48-37 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Central Michigan vs. South Alabama. You can head to SportsLine to see its picks. Here are several college football odds for South Alabama vs. Central Michigan:

  • Central Michigan vs. South Alabama spread: Central Michigan -6
  • Central Michigan vs. South Alabama over/under: 57.5 points
  • Central Michigan vs. South Alabama picks: See picks here

Why Central Michigan can cover

Central Michigan showcased its offense last week, scoring in all four quarters of its loss to No. 12 Oklahoma State. The Chippewas racked up more first downs (30) than the Cowboys (27) and recorded 544 total yards of offense. Oklahoma State was one of the top defensive teams in the country last year, so Central Michigan should have no problem moving the ball against South Alabama.

The Jaguars did not get tested in their season opener against Nicholls State, taking an early lead before cruising to the finish line. Central Michigan's game against a top-15 opponent will have the Chippewas better prepared for this contest. South Alabama has failed to cover the spread in six consecutive road games, while Central Michigan has covered in six straight games overall. 

Why South Alabama can cover

South Alabama brings more positive energy into this matchup than its opponent after rolling to a 48-7 win over Nicholls State last week. Toledo transfer Carter Bradley threw for three touchdowns and rushed for another in his South Alabama debut. He completed 17 of 25 passes for 260 yards in three quarters, giving him a solid foundation heading into this game.

Running back La'Damian Webb added 98 rushing yards and two touchdowns on 18 carries, while Jalen Wayne had three receptions for 98 yards and two scores. The Jaguars were a top-40 defense last year and held Nicholls to 165 total yards in Week 1. Central Michigan has a 4-13 record in its last 17 games in the month of September. 

How to make Central Michigan vs. South Alabama picks

The model has simulated Central Michigan vs. South Alabama 10,000 times and the results are in. It is is leaning Under on the total, and it's also generated a point-spread pick that is hitting in well over 60% of simulations. You can only see the pick at SportsLine.

So who wins South Alabama vs. Central Michigan? And which side of the spread hits in well over 60% of simulations? Visit SportsLine now to find out which side of the Central Michigan vs. South Alabama spread you need to jump on Saturday, all from the model that has crushed its college football picks, and find out.