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The 21st-ranked Wake Forest Demon Deacons look to turn the tables on the fifth-ranked Clemson Tigers when they meet in an ACC Atlantic Division matchup on Saturday at Winston-Salem, N.C. The Demon Deacons (3-0) look for their first win over Clemson since a 12-7 victory in 2008. The Tigers (3-0) defeated Wake Forest 48-27 in last year's meeting, their 13th consecutive in the series, handing the Demon Deacons their only conference loss on the season. Clemson is 69-17-1 overall in the series, including a 26-10-1 edge in games played at Wake Forest.

Kickoff from Truist Field is set for noon ET. Clemson is 63rd in the nation in total offense, averaging 425 yards per game, while Wake Forest is 57th nationally at 434.4. The Tigers are favored by 7.5 points in the latest Clemson vs. Wake Forest odds from Caesars Sportsbook, while the over-under for total points scored is 56. Before making any Wake Forest vs. Clemson picks, you need to see the college football predictions and betting advice from SportsLine's advanced computer simulation model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,300 for $100 players on its top-rated college football picks against the spread. It enters Week 4 of the 2022 college football season on a 51-43 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Clemson vs. Wake Forest and just locked in its picks and CFB predictions. You can head to SportsLine now to see the model's picks. Now, here are several college football odds and betting lines for Wake Forest vs. Clemson:

  • Clemson vs. Wake Forest spread: Clemson -7.5
  • Clemson vs. Wake Forest over/under: 56 points
  • Clemson vs. Wake Forest money line: Clemson -305, Wake Forest +240
  • CLEM: The Tigers are 4-0 against the spread in their last four conference games
  • WF: The Demon Deacons are 4-1 ATS in their last five games in September
  • Clemson vs. Wake Forest picks: See picks at SportsLine

Why Clemson can cover

Through three games, Clemson sophomore running back Will Shipley is on a record scoring pace. He has two rushing TDs in each of Clemson's first three games, and has six touchdowns on the season. He is the first Clemson player dating back to 1950 to rush for multiple touchdowns in each of the first three games of a season. Shipley is one of just three players in the nation with multiple rushing touchdowns in three different games this season. Since 2000, Shipley is one of only five ACC players -- and one of only three ACC running backs - to rush for multiple touchdowns in each of a season's first three games.

In last week's 48-20 win over Louisiana Tech, junior quarterback DJ Uiagalelei improved to 14-4 as Clemson's starting quarterback as he completed 17 of 29 passes for 221 yards with two touchdowns and no interceptions. Uiagalelei also rushed nine times for a season-high 62 rushing yards, one shy of his career high set in 2021 at North Carolina State. Uiagalelei is one of only 13 quarterbacks in Clemson history to record at least one 300-yard passing game. He is also one of only seven to record multiple 300-yard passing games.

Why Wake Forest can cover

Junior Christian Turner and sophomore Justice Ellison make for a solid one-two punch at running back for the Demon Deacons. Turner leads the team in rushing, carrying 31 times for 149 yards (4.8 average) and two scores, while Ellison has 31 carries for 113 yards (3.6 average) and one touchdown. Turner ran for a career-high 100 yards and two touchdowns, including a 35-yard score against VMI in the season opener. Ellison ran for 80 yards on 13 carries, including a game-high 45 yard run that same game.

Also helping power the offense is redshirt junior wide receiver A.T. Perry. In three starts, he has 12 receptions for a team-high 222 yards and 18.5 average with one touchdown. Last season, Perry set the single-season record with 15 touchdown receptions, three more than any other player in Wake Forest history. He was also a Biletnikoff Award semifinalist.

How to make Wake Forest vs. Clemson picks

SportsLine's model is leaning Over on the point total, projecting the teams to combine for 68 points. The model also says one side of the spread hits in well over 50% of simulations. You can only see the model's CFB picks at SportsLine.

So who wins Clemson vs. Wake Forest? And which side of the spread hits in well over 50% of simulations? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has crushed its college football picks, and find out.