darian-mensah-duke-blue-devils
Imagn Images

The ACC and Big 12 clash in the 2025 Sun Bowl on Wednesday as the Duke Blue Devils take on the Arizona State Sun Devils. Duke finished the regular season strong, knocking off rivals UNC and Wake Forest before upsetting Virginia in the ACC Championship Game. ASU won three of its last four down the stretch, but that one loss was a 23-7 setback to rival Arizona in the regular-season finale. The Sun Devils will be without quarterback Sam Leavitt (portal/injured), star receiver Jordyn Tyson (opt out) and running back Raleek Brown (opt out), among others. Duke's opt outs are edge rusher Vincent Anthony Jr., cornerback Chandler Rivers and offensive tackle Brian Parker II.

Kickoff from the Sun Bowl in El Paso, Texas is at 2 p.m. ET. The Blue Devils are 3.5-point favorites in the latest Duke vs. Arizona State odds, while the over/under is 48.5. Before making any Arizona State vs. Duke picks, check out the college football predictions from the SportsLine Projection Model. 

Be sure to watch this game on CBS, and stream on Paramount+, where you can get a free 7-day trial. 

New users can target the DraftKings promo code, which offers $200 in bonus bets if your $5+ bet wins:

The model simulates every FBS game 10,000 times, and it is 31-19 on its top-rated college football money-line picks since the beginning of the 2024 season. 

Now, the model has set its sights on Arizona State vs. Duke. You can visit SportsLine now to see the picks. Here are the FBS college football odds and trends for Duke vs. Arizona State:

Arizona State vs. Duke spread

Duke -3.5

Arizona State vs. Duke over/under

48.5 points

Arizona State vs. Duke money line 

Duke -170, ASU +142

Arizona State vs. Duke picks

See picks at SportsLine

Arizona State vs. Duke streaming 

Paramount+ (try for free)

New users can also check out the latest FanDuel promo code and get $250 in bonus bets at FanDuel if your $5 bet wins. 

How to make Duke vs. Arizona State picks

After simulating this matchup 10,000 times, SportsLine's model is going Over on the total (48.5 points). Both teams have seen two of their past three games go Over. 

Duke is in a strong spot from a roster standpoint, especially on offense. Quarterback Darian Mensah is returning to school next year and will play in this game. All of his top skill player should be available as well with the Blue Devils looking to carry their momentum from late in the season into this matchup. 

Sixth-year veteran Jeff Sims has stepped in at quarterback for ASU, giving the Sun Devils an experienced option with Leavitt out. The model is projecting 56 combined points as the Over hits well over 60% of the time. 

The model also says one side of the spread hits more than 50% of the time. You can see the model's pick at SportsLine.  

So who wins Arizona State vs. Duke, and which side of the spread hits more than 50% of the time? Visit SportsLine now to see which side of the spread to jump on, all from the advanced model that's simulated this game 10,000 times, and find out.