Red Sox's Zack Littell: Loses 40-man spot

The Red Sox designated Littell for assignment Wednesday, Ian Browne of MLB.com reports.

Littell has lost his roster spot to James Paxton (hamstring), who was activated from the 15-day injured list in advance of his season debut Friday versus the Cardinals. The 27-year-old allowed three earned runs in three innings (two relief appearances) during his brief stay with Boston.