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Trainer Antonio Sano will try to win the Fountain of Youth Stakes for the second time when he sends out the favored Simplification in the 2022 Fountain of Youth Stakes on Saturday at Gulfstream Park. The South Florida-based trainer won the 2017 edition of the Fountain of Youth with Gunnevera, who went on to win more than $5.5 million in his career. On Saturday, Simplification is the 5-2 morning-line favorite in the 2022 Fountain of Youth odds. The Todd Pletcher-trained Emmanuel is 3-1 in the 12-horse 2022 Fountain of Youth lineup.

Post time for the $400,000 Fountain of Youth is 5:42 p.m. ET. With a large field entering the starting gate on Saturday, you'll want to see what SportsLine racing insider and Beyer Speed Figure maker Bob Weir has to say before making any 2022 Fountain of Youth Stakes picks.

A Saratoga Springs-based racing insider and Beyer Speed Figure maker, Weir has twice qualified for the prestigious National Horseplayers Championship in Las Vegas. He also has produced multiple five-figure days at the track over the years, including a $60,000 Pick 6 at Del Mar in 2014. Last year, he was on fire. He hit the exacta in the Sam F. Davis Stakes, Tampa Bay Derby and Peter Pan Stakes, the trifecta in the Risen Star Stakes, Blue Grass Stakes and Pennsylvania Derby and the superfecta in the Belmont Stakes. Those were just some of his scores in 2021.

Last Sunday, he nailed the Pick 4 at Gulfstream Park, the site of Saturday's race. Anyone who has followed his lead is way up. Now, he has handicapped the 2022 Fountain of Youth Stakes entries, made his picks and constructed his bets. You can only see them here.

Top 2022 Fountain of Youth Stakes predictions

One surprise: Weir is high on In Due Time, even though he's an underdog at 6-1 on the morning line. A son of budding sire Not This Time, In Due Time is making his stakes debut after winning two of his first three starts. In his last outing, he crushed a strong allowance field, winning by 5 3/4 lengths.

In that race, he earned a Beyer Speed Figure of 92, which is the best in the field. "He continues to work well out of that effort and looks ready for the step up," Weir told SportsLine. Weir is using In Due Time prominently on his tickets.

How to make 2022 Fountain of Youth Stakes picks, bets

Weir's top pick is a horse "with something to prove." He also is high on two double-digit long shots who could net you a massive payday. Weir is including these horses in his 2022 Fountain of Youth Stakes bets, and so should you. He's sharing which horses to back only at SportsLine.

So what horse wins the 2022 Fountain of Youth Stakes? What double-digit long shots are must-backs? And how has Weir constructed his wagers? Check out the latest Fountain of Youth odds below, then visit SportsLine to see Weir's picks for the Fountain of Youth Stakes, all from the expert who evaluates horses for a living on Beyer's speed team.

2022 Fountain of Youth Stakes odds, contenders, horses, lineup

Post #HorseOddsProjection
1Markhamian20-1SEE PICKS
2Simplification5-2SEE PICKS
3Howling Time15-1SEE PICKS
4In Due Time6-1SEE PICKS
5Dean Delivers15-1SEE PICKS
6Rattle N Roll8-1SEE PICKS
7A. P.'s Secret15-1SEE PICKS
8Emmanuel3-1SEE PICKS
9High Oak8-1SEE PICKS
10Giant Game15-1SEE PICKS
11O Captain30-1SEE PICKS
12Mo DonegalSCR
13Galt15-1SEE PICKS