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The Arizona Diamondbacks and Cincinnati Reds will both be hoping to snap losing skids when they square off on Monday evening. Arizona has lost three of its last four games after dropping the final two games of its series at Pittsburgh over the weekend, while Cincinnati lost three straight against Washington. Diamondbacks starting pitcher Madison Bumgarner is 3-5 with a 4.24 ERA in 11 career starts against the Reds.

Meanwhile, Cincinnati rookie Hunter Greene is getting set for his first career start against Arizona. The Reds are -125 favorites in the latest MLB odds at Caesars Sportsbook. Before you make your MLB picks or parlays, be sure to check out the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 52-37 roll on top-rated MLB money-line picks through nine weeks, returning over $800 for $100 players. Anyone following it has seen huge returns.

Now, the model has locked in four confident MLB best bets for Monday. They all involve games at 7:10 p.m. ET or later, so there's still time to get these MLB picks in. If you successfully parlay the picks, you'd be looking at a payout of more than 12-1. You can see the model's MLB picks for Monday only at SportsLine. 

Top MLB picks today

After simulating every game 10,000 times, one pick the model likes for Monday is San Diego to beat the New York Mets as a -115 favorite at 9:40 p.m. ET (see tickets at StubHub). The Padres are entering this series on a three-game winning streak after outscoring Milwaukee 17-4 over the final three games of their weekend set. Starting pitcher Blake Snell is making his fourth start of the season for San Diego after opening the season on the injured list.

Snell held St. Louis to two runs on two hits across six innings of work his last time out. Padres manager Bob Melvin said that there are no longer any restrictions on Snell, who won the American League Cy Young Award in 2018. New York starter Carlos Carrasco has posted a 5.06 ERA on the road this season, giving the Padres an edge on Monday night. 

How to make MLB picks and parlays for Monday

The model also locked in three other best bets for Monday, including an underdog pick that hits in well over 50 percent of simulations. You can only see the model's MLB parlay picks and best bets for Monday at SportsLine. 

What MLB picks should you target for a payout of more than 12-1? And what underdog is the model strongly backing on Monday? Visit SportsLine now to see the MLB best bets for Monday from a model that has a 52-37 record on top-rated MLB money-line picks through nine weeks, and find out.