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The Toronto Blue Jays and Baltimore Orioles close out their key four-game series when they square off on Wednesday in Baltimore. The Blue Jays (75-60) own the third and final wild card spot in the American League, 3.5 games ahead of the Orioles (72-64). Toronto won the first two games of the series, while Baltimore rebounded with a win on Tuesday. Toronto is a -145 favorite in the latest Blue Jays vs. Orioles odds from Caesars Sportsbook while Baltimore is a +122 underdog.

First pitch is set for 7:05 p.m. ET from Oriole Park at Camden Yards. The game is one of 17 on the MLB schedule for Wednesday. Elsewhere in the majors, the Mets and Pirates play a doubleheader in Pittsburgh, and the Yankees and Twins play a doubleheader in the Bronx. Before making any MLB picks or parlays, be sure to see the predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is a 311-271 on top-rated MLB money-line picks since the start of the 2021 season. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win the World Series. Anybody who has followed the model has seen profitable returns.

Now, the model has locked in four confident MLB best bets for Wednesday. They all involve games at 6:45 p.m. ET or later, so there's still time to get these MLB picks in. If you successfully parlay the picks, you'd be looking at a payout of more than 12-1. You can only see the model's MLB picks at SportsLine. 

Top MLB picks today

The model, which ran 10,000 simulations on each of Wednesday's games, likes Kansas City (+118) to beat Cleveland. The Royals have one of the top rookies in the AL in shortstop Bobby Witt Jr. The No. 2 overall pick in the 2019 MLB Draft, Witt leads the team in batting average (.246) and RBI (70) and is tied for the team lead in home runs (20).

In addition, Kansas City starter Zack Greinke has owned Cleveland in two starts this season. On April 7, he gave up only one run on five hits in 5.2 innings in a no-decision against the Guardians. Then on July 10, he allowed just three hits and did not give up a run in five scoreless innings in a 5-1 Royals win. See who else to back right here.

How to make MLB picks and parlays for Wednesday

The model also locked in three other best bets for Wednesday, including a play on an even bigger underdog. You can see the model's MLB Wednesday best bets and parlay only at SportsLine.

What MLB picks should you target for a payout of more than 12-1? And what underdog does the model like on Wednesday? Visit SportsLine now to see the MLB best bets from an advanced model that is on a 311-271 run on top-rated MLB money-line picks since the start of 2021.