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The Houston Astros (62-32) and the Seattle Mariners (51-43) match up on Saturday for a battle between divisional rivals. Houston is in first place in the AL West standings while Seattle currently sits 11 games back and in second place. The Mariners are looking to redeem themselves after dropping 5-2 in the first game of the series on Friday night.

The first pitch is set for 4:10 p.m. ET from Seattle. Houston is the -165 money line favorite (risk $165 to win $100) in the latest Astros vs. Mariners odds from Caesars Sportsbook, while Seattle is a +140 underdog. The over-under for total runs scored is seven. Before making any Mariners vs. Astros picks, be sure to check out the latest MLB predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is 280-240 on top-rated MLB money-line picks since the start of the 2021 season, returning over $500 for $100 players. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on Astros vs. Mariners, and just revealed its coveted picks and predictions. You can head to SportsLine to see all of the model's MLB picks. Here are several MLB odds and betting lines for Mariners vs. Astros:

  • Astros vs. Mariners money line: Houston -165, Seattle +140
  • Astros vs. Mariners run-line: Seattle +1.5 (-135)
  • Astros vs. Mariners over-under: seven runs
  • HOU: Astros are 4-1 in their last five road games
  • SEA: Mariners are 4-0 in their last four Saturday games
  • Astros vs. Mariners picks: See picks at SportsLine.

Why you should back the Astros

Left fielder Yordan Alvarez is a polished slugger with a powerful stroke. Alvarez is a run producer with the strength to consistently drive the ball into all gaps. The 2022 All-Star ranks 10th in the majors in batting average (.310), third in home runs (28), eighth in RBI (65), and first in OPS (1.084). In his last outing, he was 1-for-2 with a two-run homer.

Right fielder Kyle Tucker has a smooth swing with superb hands and plate coverage. Tucker is a constant run-producer with home-run power as the 2022 All-Star had a great first half of the year and will look to continue his solid campaign. Tucker is tied for ninth in the league in RBI (62) along with 18 dingers.

Why you should back the Mariners

First baseman Ty France is a solid run-producer with the capability to create power in his swing. France has good awareness of the strike zone and uses that to his advantage, and the 28-year-old tallied his first All-Star Game appearance after a great first half of the year. France is 12th in the league in batting average (.307) with 12 home runs and 50 RBI.

Shortstop J.P. Crawford is a patient hitter with amazing pitch recognition skills. Crawford has quick hands with gap-producing power. The 27-year-old also plays solid defense for the Mariners and was the 2020 AL Gold Glove winner at his position. He's batting .264 with five home runs and 25 RBI, while ranking third on the team in both hits (83) and runs scored (42).

How to make Astros vs. Mariners picks

SportsLine's model is leaning over on the total, projecting 8.7 combined runs. It also says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

So who wins Mariners vs. Astros? And which side has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.