The Chicago Cubs will look to continue their home dominance over the San Francisco Giants when they meet in a key National League matchup on Friday afternoon. Chicago has won the last four meetings with San Francisco at Wrigley Field and eight of the last nine. The Cubs (65-76), who are out of the playoff picture, have won eight of 10 overall and are playing the role of spoiler. The Giants (90-50), who have won six of 10, hold a 2.5 game edge over the Los Angeles Dodgers in the NL West with 22 games remaining.

The game is slated to begin at 2:20 p.m. ET from Chicago. San Francisco is ninth in MLB in team batting average at .246, while Chicago is 28th at .232. The Giants are a -140 favorite on the money line in the latest Giants vs. Cubs odds from Caesars Sportsbook, while the over-under for total runs scored is 9.5. Before making any Cubs vs. Giants picks, check out the latest MLB predictions from the SportsLine Projection Model

This model, which simulates every game 10,000 times, is 179-150 on top-rated MLB money-line picks through 23 weeks in the 2021 season, returning almost $500. It also had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line picks. Anyone following it has seen some HUGE returns!

Now, the model has dialed in on Cubs vs. Giants and revealed its predictions and best bets. You can visit SportsLine now to see its MLB picks. Here are the MLB odds and betting trends for Giants vs. Cubs:

  • Giants vs. Cubs money line: San Francisco -140, Chicago +130
  • Giants vs. Cubs run line: San Francisco -1.5
  • Giants vs. Cubs over-under: 9.5 runs
  • SF: The Giants are 17-5 in their last 22 games following an off day
  • CHC: The Cubs are 6-1 in their last seven home games
Featured Game | Chicago Cubs vs. San Francisco Giants

Why you should back the Giants

Third baseman/outfielder Kris Bryant, a former Chicago Cub, has been a big addition to San Francisco's lineup since being acquired at the trade deadline. In 31 games with the Giants, Bryant is hitting .265 with eight doubles, six homers and 14 RBIs. He has hits in 10 of the last 14 games, including multiple hits in three of those games, such as his 2-for-4 performance against the Dodgers on Saturday night. This will be the first time he has faced his former team.

Shortstop Brandon Crawford has been hot of late with three multi-hit games over his past five. On Tuesday at Colorado, Crawford was 3-for-5 with a double and an RBI in a 12-3 victory. He was 5-for-8 with two doubles and two RBIs in the weekend series vs. the Dodgers. Crawford has feasted on Cubs pitching this year as in three games, he is 5-for-10 with two doubles, one homer and five RBIs.

Why you should back the Cubs

Despite trading away a number of key pieces from its 2016 championship team at this year's trade deadline, Chicago has played well of late, winning four of its last five series. It had a seven-game winning streak snapped on Tuesday by Cincinnati. Catcher Willson Contreras was a big reason for Chicago's success against the Reds this week, going 3-for-12 with a homer and RBI. He has also hit Giants pitching well and is batting .273 against them in four games in 2021.

Right-hander Kyle Hendricks (14-6, 4.65 ERA) will take the mound for the Cubs. He leads the team in wins, including a 4-3 triumph over the Giants on June 6. In that game, Hendricks allowed just three earned runs on seven hits in 6.1 innings while walking three and striking out five. That was also part of a stretch which saw him win eight decisions in a row. His last win was at Cincinnati on Aug. 17, when he allowed one earned run on three hits in six innings of work. 

How to make Giants vs. Cubs picks

SportsLine's model is leaning under on the total, as the simulations have the teams combining for 9.1 runs. It also says one side of the money line hits in almost 60 percent of simulations. You can only get the pick at SportsLine.

So who wins Cubs vs. Giants? And which side of the money line hits in almost 60 percent of simulations? Visit SportsLine now to see which side to back, all from the advanced model that's on a roll on its MLB picks, and find out.