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NL Central foes square off when the Pittsburgh Pirates (13-18) host the Cincinnati Reds (8-24) on Friday evening. Cincinnati picked up a win in the first matchup, but Pittsburgh is looking to bounce back and even the series. The Reds are currently on a two-game win streak. Meanwhile, Pittsburgh is 1-2 in its last three games. Tyler Mahle (1-2, 6.46 ERA) gets the start for the Reds. Mitch Keller (0-4, 6.11 ERA) is on the hill for Pittsburgh.

The first pitch is set for 6:35 p.m. ET. Caesars Sportsbook lists both sides at -110 on the money line (risk $110 to win $100) in the latest Reds vs. Pirates odds. The over-under for total runs scored is eight. Before making any Pirates vs. Reds picks, you need to check out the MLB predictions and betting advice from SportsLine's advanced computer simulation model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a sizzling start to the 2022 season. It's on a 31-19 roll on top-rated MLB money-line picks through five weeks, returning almost $800 for $100 players. Anyone following it has seen huge returns.

Now, the model has set its sights on Pirates vs. Reds, and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Now, here are several MLB odds and betting lines for Reds vs. Pirates:

  • Reds vs. Pirates money line: Pittsburgh -110, Cincinnati -110
  • Reds vs. Pirates run line: Cincinnati -1.5 (+145)
  • Reds vs. Pirates over-under: 8 runs
  • CIN: The Reds are 4-1 in their last five vs. the NL Central
  • PIT: The Pirates are 4-0 in their last four games following a loss

Why you should back the Pirates

Left fielder Bryan Reynolds is a smooth switch-hitter with solid bat speed. Reynolds can hit for average but also runs well on the field. The 2021 All-Star has quick instincts and good recovery speed in the outfield for Pittsburgh. Reynolds has recorded four homers with six RBI. On May 10, he went 1-for-3 with a double.

Outfielder Ben Gamel is a stable hitter with untapped power and pop in his swing. The 29-year-old has decent plate discipline and can be overaggressive at times. Gamel's batting average is .299 with a team-high 14 RBI. In his last outing, he went 2-for-4 with two singles. 

Why you should back the Reds

Third baseman Brandon Drury is a natural run-producer with terrific bat speed and control. Drury is a reliable defender in the corner with solid instincts. He owns a strong throwing arm and good hands. The 29-year-old leads the team in batting average (.253), home runs (6) with 18 RBI. On May 9, Drury went 2-for-5 with a three-run homer.

Left fielder Tommy Pham displays a good combination of power and speed. Pham can hit for average with a line-drive swing. The 34-year-old is flexible on the back end and can play all three outfield spots. Pham has a batting average of .245 with four homers and 11 runs driven in. On May 11, he went 3-for-4 with three singles and two RBI.

How to make Reds vs. Pirates picks

SportsLine's model is leaning over on the total, projecting 9.7 combined runs. It also says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

So who wins Pirates vs. Reds? And which side has all the value? Visit SportsLine now to see which side of the money line you need to jump on, all from the model that has crushed its MLB picks, and find out.