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The Memphis Grizzlies will take on the Charlotte Hornets at 8 p.m. ET on Wednesday at the FedExForum. The Grizzlies is 6-4 overall and 4-1 at home, while Charlotte is 5-7 overall and 3-5 on the road. The Grizzlies won both regular-season matchups between these teams last season.

Memphis is favored by 4.5-points in the latest Grizzlies vs. Hornets odds from Caesars Sportsbook, and the over-under is set at 229. Before entering any Hornets vs. Grizzlies picks, you'll want to see the NBA predictions from the proven computer model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned over $9,000 in profit on its top-rated NBA picks over the past three-plus seasons. The model enters Week 4 of the 2021-22 NBA season up over $500 on all top-rated NBA picks this season. It's also on a stunning 110-73 roll on top-rated NBA picks against the spread that dates back to last season. Anyone following it has seen huge returns.

Now, the model has set its sights on Grizzlies vs. Hornets. You can head to SportsLine to see its picks. Here are several NBA betting lines for Hornets vs. Grizzlies:

  • Grizzlies vs. Hornets spread: Grizzlies -4.5
  • Grizzlies vs. Hornets over-under: 229 points

What you need to know about the Grizzlies

It may have taken overtime to finish the job, but the Grizzlies ultimately got the result they were hoping for on Monday with a 125-118 victory over the Minnesota Timberwolves. Memphis outscored Minnesota 44-26 over the course of the fourth quarter and overtime period. Point guard Ja Morant did his thing and had 33 points and eight assists along with six boards.

Forward Dillon Brooks, who started 140 games over the last two seasons, has yet to play this year due to a hand injury but is listed as questionable for Wednesday. Also questionable is No. 10 draft pick Ziaire Williams due to right wrist soreness. Regardless if these two suit up, Memphis will be hoping for a better effort on the defensive end as the 113.8 points per game it allows is the second-worst mark in the NBA.

What you need to know about the Hornets

Meanwhile, Charlotte fought the good fight in its overtime matchup against the Los Angeles Lakers on Monday but wound up with a less-than-desirable result, falling 126-123. The losing side was boosted by point guard LaMelo Ball, who posted a triple-double with 25 points, 15 rebounds, and 11 dimes.

Only one team allows more points per game than Memphis and that is Charlotte. The Hornets are giving up 118.3 points per contest, which is nearly seven more points than they allowed last season. The Hornets will also be shorthanded on Wednesday as forward P.J. Washington is out with an elbow injury.

How to make Grizzlies vs. Hornets picks

The model has simulated Hornets vs. Grizzlies 10,000 times and the results are in. We can tell you that the model is leaning under, and it's also generated a point-spread pick that is hitting in well over 60 percent of simulations. You can only see the pick at SportsLine.

So who wins Grizzlies vs. Hornets? And which side of the spread has all the value? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that has crushed its NBA picks, and find out.