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The Brooklyn Nets will take on the Philadelphia 76ers at 8 p.m. ET Saturday at Wells Fargo Center. The Nets are 14-10 overall and 4-5 on the road, while Philadelphia is 16-7 overall and 10-2 at home. The Sixers are 12-9 against the spread this season. Brooklyn has a 10-14 ATS mark for the year. 

Philadelphia is favored by 4.5 points in the latest Nets vs. Sixers odds from William Hill Sportsbook, and the over-under is set at 236.5. Before making any Nets vs. Sixers picks, you'll want to see the NBA predictions from the model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times, and it returned over $5,000 in profit on its top-rated NBA picks last season. The model is up nearly $8,100 over the past two-plus seasons. Dating back to last season, it is also on a stunning 73-44 roll on top-rated picks against the spread. Anybody who has followed it has seen huge returns.

Now, the model has set its sights on Nets vs. 76ers. You can head to SportsLine to see its picks. Here are several NBA betting lines for 76ers vs. Nets:

  • Nets vs. Sixers spread: Nets +4.5
  • Nets vs. Sixers over-under: 236.5 points

What you need to know about the Nets

The Nets lost to the Raptors on Friday, 123-117. Brooklyn has lost two of its past three games. Kevin Durant was removed from the game in the third quarter after not being cleared for the start of the game due to health and safety protocols. He will not play on Saturday night. He scored eight points in 19 minutes. 

Kyrie Irving will not play on Saturday because of a finger injury. Joe Harris led the Nets with 19 points on Friday. James Harden leads the league in assists per game at 11.3. He had 12 vs. Toronto. 

What you need to know about the Sixers

The Sixers lost to the Blazers on Thursday night, 121-105. It was just the second home loss of the season for Philadelphia. The Sixers still have the best home record in the NBA. Joel Embiid scored 32 of his 37 points in the first half. Philadelphia was outscored 40-19 in the third quarter. Embiid (knee) and Seth Curry (illness) are both questionable for this matchup. Ben Simmons (calf) is probable. 

The Sixers missed 20 of 27 3-point attempts on Thursday. The loss stopped a four-game winning streak for Philadelphia. The Sixers lost the first meeting of the season with the Nets on Jan. 7, 122-109.   

How to make Nets vs. Sixers picks

The model has simulated Nets vs. Sixers 10,000 times and the results are in. It is leaning over on the total, and it's also generated a point-spread pick that is hitting in almost 70 percent of simulations. You can only see the pick at SportsLine.

So who wins Nets vs. Sixers? And which side of the spread hits in almost 70 percent of simulations? Visit SportsLine now to see which side of the Nets vs. Sixers spread to jump on Saturday, all from the model that is on an incredible 73-44 roll.