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The Denver Broncos and Jacksonville Jaguars will try to right the ship on Sunday. A full Sunday of action begins with this AFC matchup, and the two teams will meet at Wembley Stadium as part of the 2022 NFL in London series. Denver is 2-5 overall and looking to stop a four-game losing streak. Jacksonville (2-5) has also lost four in a row, including a Week 7 loss to the New York Giants.

Kickoff is at 9:30 a.m. ET in London. Caesars Sportsbook lists the Jaguars as 2.5-point favorites, while the over/under, or total number of points Vegas thinks will be scored, is 40.5 in the latest Broncos vs. Jaguars odds. Before you make any Jaguars vs. Broncos picks, you need to see the NFL predictions and betting advice from SportsLine's advanced computer model.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 8 of the 2022 NFL season on an incredible 148-107 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Broncos vs. Jaguars and just locked in its picks and Week 8 NFL predictions. You can head to SportsLine now to see the model's picks. Now, here are several NFL odds and betting lines for Broncos vs. Jaguars:

  • Broncos vs. Jaguars spread: Jaguars -2.5 
  • Broncos vs. Jaguars over/under: 40.5 points 
  • Broncos vs. Jaguars money line: Jaguars -140, Broncos +118 
  • DEN: Broncos are 2-5 against the spread this season 
  • JAX: Jaguars are 2-5 against the spread this season 
  • Broncos vs. Jaguars picks: See picks here

Why the Broncos can cover

The Broncos have only eight turnovers and four interceptions this season, ranking in the top 10 in both categories. Denver is also facing a Jacksonville defense that is No. 22 in first downs allowed and below-average in passing yards allowed. On defense, the Broncos are in the top three in scoring defense and total defense, yielding only 16.4 points and 286 total yards per game.

Denver is No. 1 in points allowed per drive and yards allowed per drive and top-five in first downs allowed, touchdown passes allowed, passing yards allowed, net yards allowed per pass attempt, third down conversion rate, and red zone efficiency. Jacksonville is scoring only 17.8 points per game in the last four contests, and Denver enjoyed success against the Jaguars in a 2021 matchup, holding Jacksonville to 13 points and 118 passing yards. See which team to back here.

Why the Jaguars can cover

The Jaguars are giving up only 19.6 points per game, a top-10 mark, and Jacksonville is opportunistic with seven interceptions. Jacksonville is also in the top five in yards per carry allowed (4.1), while the Broncos are dead-last in scoring, averaging 14.3 points per game. Denver is also dead-last in red zone efficiency, scoring a touchdown on only 24% of trips inside the 20-yard line, and the Broncos are second-worst in third down conversion rate at 30%.

The Broncos are also in the bottom 10 in total yards and first downs, throwing only five touchdown passes all season. On the ground, Denver is better, but the Broncos are averaging only 4.2 yards per carry, so Jacksonville can load up to stop the running game in this matchup. See which team to back here.

How to make Broncos vs. Jaguars picks

SportsLine's model is leaning Under on the point total, with both teams projected to throw for fewer than 225 yards. The model also says one side of the spread hits in well over 50% of simulations. You can only see the model's pick at SportsLine.

So who wins Broncos vs. Jaguars in London? And which side of the spread hits in well over 50% of simulations? Visit SportsLine now to see which side of the Broncos vs. Jaguars spread you need to jump on Sunday, all from the model that has crushed its NFL picks, and find out.