james-conner-cardinals-getty.jpg
Getty Images

The Arizona Cardinals will take on the Carolina Panthers at 4:05 p.m. ET on Sunday at State Farm Stadium. Arizona is 8-1 overall and 3-1 at home, while Carolina is 4-5 overall and 2-2 on the road. Arizona bounced back from its first loss with a win in Week 9. Carolina has lost five of its past six games. 

The Panthers have won the last three games between the teams, including a 31-21 victory last October. Arizona is favored by 10.5 points in the latest Cardinals vs. Panthers odds from Caesars Sportsbook, and the over-under is set at 44. Before entering any Panthers vs. Cardinals picks, you'll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,600 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 10 of the 2021 season on an incredible 128-88 run on top-rated NFL picks that dates back to the 2017 season. 

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Cardinals vs. Panthers. You can head to SportsLine to see its picks. Here are several NFL betting lines for Panthers vs. Cardinals:

  • Cardinals vs. Panthers spread: Cardinals -10.5
  • Cardinals vs. Panthers over-under: 44 points

What you need to know about the Panthers

The Panthers lost to the New England Patriots last week, 24-6. Sam Darnold threw three interceptions with a passing completion percentage of 48.4. Darnold was placed on injured reserve this week with a shoulder injury. P.J. Walker will start vs. the Cardinals, and the Panthers also signed Cam Newton this week, though coach Matt Rhule said Newton likely won't be active for this game.

The Panthers are stumbling into Week 10 with the second-fewest passing touchdowns in the league, with seven on the season. Christian McCaffrey returned to action last week for the first time since Week 3, as he was out with a hamstring injury. He had 106 yards from scrimmage. Brian Burns (ankle) is questionable for Sunday's game. 

What you need to know about the Cardinals

Meanwhile, Arizona beat the San Francisco 49ers last Sunday, 31-17. James Conner punched in two rushing touchdowns with 96 rushing yards in addition to catching five passes for 77 yards and a TD. He is one of two NFL players with four games of two-plus TDs this season. Markus Golden had a career-high three sacks last week and leads the NFC with nine sacks.

The Cardinals rank first in the NFL in offensive touchdowns, with 33. Kyler Murray (ankle) and DeAndre Hopkins (hamstring) did not play in Week 9 and are listed as questionable for Week 10. Budda Baker and Rondale Moore (concussions) are also questionable. 

How to make Panthers vs. Cardinals picks

The model is leaning over on the total, and it also has generated a pick that hits in over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Cardinals vs. Panthers? And which side of the spread hits more than 50 percent of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.