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The 2025 NFL Christmas Day tripleheader kicks off with Cowboys vs. Commanders at 1 p.m. ET, followed by Lions vs. Vikings at 4:30 p.m. ET, with Chiefs vs. Broncos wrapping things up at 8:15 p.m. ET. Even with some notable quarterback injuries removing big names from the NFL DFS player pool, the slate is still loaded with high-quality options to target for NFL DFS lineups. Dak Prescott, CeeDee Lamb, Jahmyr Gibbs, Justin Jefferson and Travis Kelce are just some of the stars you could consider for your daily Fantasy football lineups.

Big names, however, come equipped with big price tags, so you'll have to find balance with more affordable players as well. Those aforementioned QB injuries could make the likes of Chris Oladokun or Max Brosmer value-based Christmas NFL DFS picks. Before making any NFL DFS picks for Christmas, be sure to check out the NFL DFS advice, strategy, and stacks from SportsLine daily Fantasy expert Mike McClure.

You can also bet props like Prescott going over 1.5 passing touchdowns using the latest DraftKings promo code, which offers $200 in bonus bets if your bet wins:

McClure is a legendary professional DFS player with more than $2 million in career winnings. He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends, and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine. His methodology has led to enormous cashes on FanDuel and DraftKings, including. In 2023, he finished tied for first in the DraftKings Millionaire Maker twice and the FanDuel Million once. Anyone who has followed him could be way up.

Now, McClure has turned his attention to the Christmas NFL DFS slate and just locked in his top daily Fantasy football picks. You can only see his picks and analysis at SportsLine. 

Top NFL DFS picks for Christmas Day

Part of McClure's NFL DFS strategy for Christmas is rostering Lions running back Jahmyr Gibbs at $8,300 on DraftKings and $9,400 on FanDuel. Gibbs ranks third amongst all running backs in Fantasy points for the second straight season. He ranks eighth in scrimmage yards (1,662) and second in total touchdowns (17) ahead of a matchup with a team he has historically dominated. Gibbs has nine touchdowns in five career games versus Minnesota while averaging 97.6 scrimmage yards. The Vikings have also been unable to stop any RBs from hitting paydirt recently as each of the last six offensive TDs that Minnesota has allowed have been to running backs. See who else to roster at SportsLine.

You can also bet on Gibbs to go Over 113.5 rushing + receiving yards at DraftKings:

Another one of McClure's NFL DFS picks is Cowboys wideout George Pickens ($8,800 on FanDuel, $7,300 on DraftKings), who is coming off a 7-130-1 stat line and ranks third in the NFL with 1,342 receiving yards on the season. He's been as consistent as any receiver and has at least 78 yards or a touchdown in 12 of 15 games. He also has a salivating matchup against Washington, which has the No. 26 passing defense, and just two teams have allowed more passing touchdowns. Pickens had 82 yards against the Commanders earlier this year after having 91 yards and a score versus them last season. See more NFL DFS picks at SportsLine.

Bet Pickens to go Over 79.5 receiving yards at DraftKings:

How to set Christmas Day NFL DFS lineups

McClure is targeting another undervalued player who could explode for huge numbers on Christmas. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is, and the rest of McClure's NFL DFS picks, at SportsLine.

So who is Mike McClure including in his optimal NFL DFS lineups for Christmas Day, and which under-the-radar player offers huge value? Visit SportsLine now to see optimal NFL DFS picks, NFL DFS rankings, NFL DFS advice and NFL DFS stacks, all from a daily Fantasy expert with more than $2 million in winnings, and find out.