NFL picks this week, odds, lines, bets: Week 7, 2025 expert predictions against the spread, parlay, prop bets
SportsLine's top NFL experts reveal their NFL picks, NFL predictions, NFL betting tips and NFL best bets for Week 7

International games, bye weeks and plenty of injuries have already impacted NFL odds this season. The Week 7 NFL schedule brings the first team to be led by an interim head coach as the Titans fired Brian Callahan and replaced him with Mike McCoy ahead of a matchup with the Patriots, who are led by former Titans coach Mike Vrabel. The Pats are 7-point road favorites in the latest Week 7 NFL odds. There are plenty of NFL playoff previews on the slate as well such as Chargers (-2.5) vs. Colts, Eagles (-2.5) vs. Vikings and Lions (-5.5) vs. Buccaneers, with Detroit vs. Tampa one of two game on Monday night.
Those are just a handful of the 15 games you can make Week 7 NFL bets, prop predictions or create an NFL parlay on. Having quality NFL betting advice is almost a must with so much information and data to keep track of, especially when injuries to star players cause line movements. NFL expert predictions would go a long way in making your football bets winning ones. Before locking in any Week 7 NFL picks or NFL prop bets, be sure to check out the Week 7 NFL best bets and predictions from SportsLine's red-hot Vegas experts.
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SportsLine has more than 40 hand-picked Vegas experts who excel in multiple spots. The NFL, however, is a strength for the site as SportsLine currently has five total experts who are on NFL runs that have returned $860 or more for $100 players and one who has returned more than $2,100. Anybody following could have seen huge returns.
Now, with the Week 7 NFL schedule quickly approaching, SportsLine's top NFL betting experts are already locking in their picks. Go to SportsLine to see them all now.
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Top Week 7 expert NFL prop picks from PropStarz
Alex Selesnick, better known as 'PropStarz,' specializes in player props, and he enters the weekend of Week 7 on a 24-11 run on NFL player props that has returned more than $1,000 for $100 bettors. One of his top prop picks this week is going Over 52.5 receiving yards (-110) for Carolina receiver Tetairoa McMillan.
"We're going to buy the dip as we're getting a hefty discount on this receiving line from Tet McMillan who is operating as a clear cut WR1 and has performed well in this role despite low volume and inconsistent QB play," PropStarz said. "This is a good matchup against a Jets pass defense that ranks 30th in DVOA, 30th in EPA Per Dropback, and 28th in Coverage Grade. They've also been extremely generous to opposing number 1 WRs as they are currently dead last in 1st Read EPA. Bryce Young is attempting a first-read throw on 65% of his dropbacks, which is the fifth-highest rate in the league. He's trying to get the ball where it is supposed to go and its designed to go to McMillan." You can see all of PropStarz's NFL picks here.
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Top Week 7 NFL expert picks from Eric Cohen
Cohen has hit 65% of his straight-up NFL picks this season, and now he's locked in his picks and exact score prediction for each game during the Week 7 NFL schedule. He's taking the Patriots to beat the Titans by 10 points, covering as 7-point road favorites.
"The Brian Callahan-era may be over in Tennessee, but will it really matter than much this week? Don't you think current New England / former Tennessee coach Mike Vrabel will want to show his former organization what they're missing? I do," Cohen said. "Second year QB Drake Maye is playing at a high level and the poor Titans defense isn't going to slow him much. The Patriots win their fourth straight and move to 5-2." See all of Cohen's NFL picks and score predictions at SportsLine.
Top Week 7 NFL expert picks from Larry Hartstein
A veteran CBS Sports and SportsLine NFL expert, Hartstein is on a sizzling 14-4 run on NFL spread picks, returning nearly $1,000 for $100 bettors. This week, he's backing the Chargers (-1.5) against the Colts.
"The Colts' injury report is bleak, while the Chargers' injury report is showing some promise," Indy's banged-up secondary is something Justin Herbert can exploit, especially with Quentin Johnston expected to return. Journeyman Jacoby Brissett just threw for 320 yards and two touchdowns at Indianapolis. LA ranks No. 6 in pass efficiency defense and will pose a stiff test for the resurgent Daniel Jones. See all of Hartstein's SportsLine picks here.
How to make Week 7 NFL against the spread picks
SportsLine's team of experts also includes R.J. White, who is the site's all-time leading NFL expert and is this season's top expert as well, returning more than $2,100 on his past 112 picks. He has 14 more picks on the board, including in a game where he thinks the line is off by several points. You can find out who his NFL picks are this week here.
If you are looking for NFL picks, NFL props, or NFL best bets for Week 7, SportsLine has you covered with its proven team of experts. Visit SportsLine now to see who which teams you should back in Week 7, all from a staff that includes five experts who are on NFL runs that have returned $700 or more for $100 players.
















