The NFL's opening weekend will attract bets from the average Joe to professional bettors for some of the biggest games.
The Pittsburgh Steelers are nearly favored by double digits on the road against the division rival Cleveland Browns. And the Dallas Cowboys, who will have RB Ezekiel Elliott available, are four-point home favorites against the New York Giants on Sunday Night Football in a game that's already had plenty of line movement.
With so many eye-popping games and so many NFL odds on the move, you'll want to know to what SportsLine's advanced computer model is picking.
SportsLine's Projection Model went an amazing 174-80-2 on straight-up NFL picks last season -- better than all 98 experts tracked by NFLPickWatch.
Every single one.
SportsLine computer picks would have also won over 96 percent of CBS Sports Office Pool Manager pools that made straight up picks last season.
With Week 1 already here, the computer simulated every matchup 10,000 times and came up with some surprising results.
One team the model loves in Week 1: the Atlanta Falcons, who are 6.5-point favorites over the Chicago Bears at Soldier Field.
The Bears' defense held the Tennessee Titans' first-string offense scoreless in the first half of the Week 3 preseason game, but SportsLine's model is calling for a 29-19 blowout, with the Falcons winning 72 percent of simulations. Confidently take the defending NFC champions to cover on the road and ignore talk of a Super Bowl hangover.
Another team SportsLine's model loves: the Buffalo Bills. They're 8-point favorites at home against the New York Jets, but SportsLine's advanced computer model has the Bills winning 71 percent of simulations with a projected final score of 27-18. Take the Bills -8, even with WR Jordan Matthews' health in question. SportsLine's simulations say Bills RB LeSean McCoy has over 100 yards from scrimmage and a touchdown in this game.
A shocker: SportsLine's computers say the Washington Redskins defeat the division-rival Philadelphia Eagles 27-23. Why is that shocking? Despite playing at home, the Redskins are one-point underdogs, and the line has moved all the way from Washington -2.5. SportsLine's model calls for TE Jordan Reed to have the best chance to score among Redskins pass-catchers, while Eagles RB LeGarrette Blount rushes for just 34 yards in his debut.
The model is also calling for a home favorite to get absolutely stunned in Week 1, meaning a big payday for anyone who bets on the big-time road underdog.
What NFL picks can you make with confidence in Week 1? Check out the NFL odds below and then visit SportsLine to see which NFL teams are winning more than 50 percent of simulations, plus see which side of Cowboys-Giants is a virtual lock, all from the model that would have won 96 percent of football pools last season, as well as picks from 16 experts.
New York Jets at Buffalo Bills (-8, 40)
Atlanta Falcons at Chicago Bears (+6, 49)
Philadelphia Eagles at Washington Redskins (+1, 48)
Arizona Cardinals at Detroit Lions (+2.5, 48)
Oakland Raiders at Tennessee Titans (-3, 50.5)
Jacksonville Jaguars at Houston Texans (-5.5, 39.5)
Pittsburgh Steelers at Cleveland Browns (+9, 46.5)
Baltimore Ravens at Cincinnati Bengals (-3, 41)
Indianapolis Colts at Los Angeles Rams (-4.5, 41.5)
Seattle Seahawks at Green Bay Packers (-3, 51)
Carolina Panthers at San Francisco 49ers (+4.5, 47.5)
New York Giants at Dallas Cowboys (-4, 47.5)
New Orleans Saints at Minnesota Vikings (-3, 48)
Los Angeles Chargers at Denver Broncos (-3, 43)