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One-loss teams will face off in a highly anticipated matchup on Sunday. The Green Bay Packers and New York Giants take the field in the 32nd all-time NFL in London game. Green Bay will make its first trip to England, with New York playing in London for the third time. The clubs will also meet in NFL London 2022 for the first time since 2019, with the winner entering the middle third of the season with a 4-1 record.

Kick-off is at 9:30 a.m. ET in London. Caesars Sportsbook lists Green Bay as an 8-point favorite, while the over/under, or total number of points Vegas thinks will be scored, is 42 in the latest Giants vs. Packers odds. Before you make any Giants vs. Packers picks, you need to see the NFL predictions and betting advice from SportsLine's advanced computer model.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 5 of the 2022 NFL season on an incredible 140-105 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Giants vs. Packers and just locked in its picks and NFL Week 5 predictions. You can head to SportsLine now to see the model's picks. Now, here are several NFL odds and betting lines for Giants vs. Packers:

  • Giants vs. Packers spread: Packers -8 
  • Giants vs. Packers over/under: 42 points 
  • Giants vs. Packers money line: Packers -385, Giants +300 
  • NYG: Giants are 3-1 against the spread this season 
  • GB: Packers are 2-2 against the spread this season 
  • Giants vs. Packers picks: See picks here

Why the Giants can cover

The Giants are facing a Packers team that is averaging only 18.8 points per game, fewest for the franchise through four weeks since 2006. New York is in the top 10 in points allowed per game (17.8) and per drive (1.61), with additional top-10 marks in first downs allowed, passing yards allowed, and passing touchdowns allowed. The Giants are elite on third down, allowing opponents to convert only 29.4% of chances, and are No. 2 in red zone efficiency allowed at 35.7%.

On offense, New York leads the NFL in rushing yards with 770 through four weeks and is No. 2 at 5.8 yards per carry. That attack is headlined by Saquon Barkley, who leads the league in rushing yards, and New York posted 262 rushing yards in Week 4.

Why the Packers can cover

The Packers are No. 6 in total offense, averaging 377.5 yards per game, and in the top 10 in rushing yards (145.0 per game) and yards per carry (5.0). Aaron Rodgers leads a potent third-down offense that converts 42.6% of chances, and the four-time MVP quarterback has a 69% completion rate with a top-10 mark in passing touchdowns.

Running back Aaron Jones leads the NFL with 6.8 yards per carry and has 327 rushing yards in four games. On the other side, the Packers are in the top seven in scoring defense, total defense, first downs allowed, passing defense, and third down defense. New York is a bottom-tier team in passing offense, including the second-worst mark in yards, and the Giants land well below the NFL average in third down efficiency and red zone efficiency.

How to make Giants vs. Packers picks

SportsLine's model is leaning Over on the total, with the leading rusher for both teams projected to average at least five yards per carry. The model also says one side of the spread has all the value. You can only see the model's Giants vs. Packers picks at SportsLine.

So who wins Giants vs. Packers in London? And which side of the spread has all the value? Visit SportsLine now to see which side of the Giants vs. Packers spread you need to jump on Sunday, all from the model that has crushed its NFL picks, and find out.