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The New Orleans Saints and the Atlanta Falcons are set to square off in an NFC South matchup at 4:25 p.m. ET on Sunday at Mercedes-Benz Stadium. Atlanta is 7-9 overall and 2-5 at home, while the Saints are 8-8 overall and 5-3 on the road. The Saints can clinch an NFC playoff berth with a win and a 49ers loss. The Falcons have been eliminated from playoff competition. 

The Saints have won three of the last four games between the teams. New Orleans is favored by 3.5 points in the latest Falcons vs. Saints odds from Caesars Sportsbook, and the over-under is set at 40. Before entering any Saints vs. Falcons picks, you'll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up over $7,200 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 18 of the 2021 season on an incredible 135-96 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up!

Now, the model has set its sights on Falcons vs. Saints. You can head to SportsLine to see its picks. Here are several NFL betting lines for Saints vs. Falcons:

  • Falcons vs. Saints spread: Saints -3.5
  • Falcons vs. Saints over-under: 40 points

What you need to know about the Falcons

Atlanta lost to Buffalo Bills last Sunday, 29-15. The loss eliminated Atlanta from playoff contention. The Falcons were shut out in the second half. Foyesade Oluokun had one of three Atlanta turnovers, as he intercepted a pass for the second consecutive game. 

Kyle Pitts (hamstring) is questionable for Sunday's game. Jason Spriggs and Jonathan Bullard are in the league's health and safety protocols. 

What you need to know about the Saints

Meanwhile, New Orleans bagged an 18-10 win over the Carolina Panthers last Sunday. Cameron Jordan had a season-high 3.5 sacks in Week 17 and can become the first player since 2002 with two or more sacks in four straight games. Alvin Kamara had five catches and 100 scrimmage yards (68 receiving) with his 20th-career receiving TD last week. He has rushed for a TD in his last three games vs. the Falcons. 

Marcus Davenport (ankle), Mark Ingram (knee), and Ryan Ramczyk (knee) are questionable for Sunday's game. Terron Armstead (knee), P.J. Williams (ankle), and Bradley Roby (shoulder) are out. 

How to make Saints vs. Falcons picks

The model is leaning under on the total, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Falcons vs. Saints? And which side of the spread hits more than 50 percent of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.