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Several cross-conference NFL Week 3 games allow for fan bases to see opponents that don't come to town very often. The uniqueness of these contests are ideal to target with the latest DraftKings Pick6 promo code. The Packers will visit Cleveland for just the third time over the last 30 years, while the same goes for the Raiders going to the nation's capitol to take on the Commanders. NFL player props for these matchups, and others, will be popular forms of NFL betting. This Pick6 promotion gives new users $50 in bonus picks after a $5 bet. Click here to get the latest DraftKings Pick6 promo code for new users:

How to claim the Pick6 promotion on Sunday, September 21

Here are the steps to follow in order to sign up and claim the Pick6 promo.

1. Click "CLAIM BONUS" on this page or click here.
2. Sign up for Pick6 through the promotion offer on the app or website by entering your name, email, and payment information. Make sure you are of legal age in a state where Pick6 operates.
3. Make a deposit of at least $5 and submit an entry of at least $5.
4. Pick6 will issue five $10 entry slips as bonus picks.

Get started here:

Best Pick6 picks for September 21

(Projections from the SportsLine model)

QB Jordan Love, Packers, 225.5 passing yards - Less

Love is off to a great start but will be shorthanded on Sunday. Jayden Reed was just placed on IR, Christian Watson remains on the PUP list, and Tucker Kraft (knee) is expected to suit up but won't be at 100%. Add in that first-round pick, Matthew Golden, has made no impact with just 16 receiving yards and Love is expected to hit the Under versus a Cleveland pass defense which ranks third in the NFL. Select it at Pick6:

QB Marcus Mariota, Commanders, 205.5 passing yards - More 

In place of Jayden Daniels in Week 18 of last season, Mariota passed for 161 yards despite playing just over half of the offensive snaps. In his other significant action in 2024, the Oregon Heisman winner had 205 passing yards even though he didn't enter the game until late in the first quarter. Mariota also has an extra incentive to have a big game on Sunday as the Raiders, who rank 27th in pass defense this season, are one of his former teams. SportsLine's model projects 222 passing yards. Click here to sign up for DraftKings Pick6:

RB Ashton Jeanty, Raiders, 12.5 receiving yards - Less

Jeanty is still trying to find his sea legs in the NFL as he's averaging just 2.7 yards per carry, with 43 or fewer rushing yards in both games. He's done even less in the passing game with five receptions for a total of three yards. Raiders backup running backs, Zamir White and Dylan Laube, both have more receiving yards this season than the rookie as Jeanty simply isn't a major part of Las Vegas' aerial attack. Combine picks for a parlay on Pick6 for a potential payout of around 6x.

With the 2025 NFL season now here, the SportsLine Projection model also offers picks for every NFL picks for every game on the slate, which you can use to help guide you in making NFL picks on DraftKings Pick6.