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The No. 15 Houston Cougars will take on the Butler Bulldogs at 4:30 p.m. ET Monday at Michelob Ultra Arena. Butler is 3-1 while the Cougars are 3-0. The Bulldogs missed out on the NCAA Tournament last year while Houston advanced to the Final Four. 

The Cougars are favored by 10 points in the latest Houston vs. Butler odds from Caesars Sportsbook, and the over-under is set at 123. Before entering any Butler vs. Houston picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,100 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Houston vs. Butler. You can head to SportsLine to see its picks. Here are several college basketball odds for Butler vs. Houston:

  • Houston vs. Butler spread: Houston -10
  • Houston vs. Butler over-under: 123 points

What you need to know about Butler

Butler has to be aching after a bruising 73-52 defeat to the Michigan State Spartans last week. One thing holding the Bulldogs back was the mediocre play of guard Chuck Harris, who did not have his best game. He finished with 13 points on 4-for-16 shooting and turned the ball over four times in his 36 minutes on the court.

Butler's defense has gotten progressively worse in each game since giving up 47 points in its season opener. It then proceeded to give up 53 points vs. Central Arkansas followed by 59 points to Troy and 73 to MSU. Possessing the ball more would help the Bulldogs limit the opposition's scoring, but Butler ranks 352nd out of 358 teams with just 3.5 steals per game.

What you need to know about Houston

Meanwhile, Houston made easy work of the Virginia Cavaliers last Tuesday and carried off a 67-47 victory. Houston's guard Marcus Sasser filled up the stat sheet, picking up 19 points, four assists and three steals. The Cougars were on fire from deep as they knocked down 11-of-20 (55 percent) of their three-point attempts.

Sasser was second team All-AAC last season and is on the Preseason Wooden Award watch list this year. He currently leads the American Athletic Conference in scoring (23.3 PPG) while ranking sixth in assists (4.0 APG). Houston is also getting a nice contribution from Texas Tech transfer Kyler Edwards who ranks among the top 10 in the AAC in both scoring and rebounding.

How to make Butler vs. Houston picks

The model has simulated Houston vs. Butler 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 60 percent of simulations. You can only see the pick at SportsLine.

So who wins Butler vs. Houston? And which side of the spread hits well over 60 percent of the time? Visit SportsLine now to see which side of the spread to jump on, all from the advanced model that is up nearly $2,100 on its college basketball picks the last five years, and find out.