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The Virginia Cavaliers and the Louisville Cardinals take their turn in the ACC Tournament at 9:30 p.m. ET on Wednesday at the Barclays Center. Louisville finished the regular season 14-18, and won just once in its final 12 games, while the Cavaliers wrapped things up at 18-12. Virginia has dominated this series in recent years, winning nine of its last 10 meetings against Louisville. 

The Cavaliers are favored by six points in the latest Virginia vs. Louisville odds from Caesars Sportsbook, and the over-under is set at 122.5. Before entering any Louisville vs. Virginia picks, you'll want to see the college basketball predictions from the advanced computer model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $1,600 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Virginia vs. Louisville. You can head to SportsLine to see its picks. Here are several college basketball odds for Virginia vs. Louisville:

  • Virginia vs. Louisville spread: Virginia -6
  • Virginia vs. Louisville over-under: 122.5 points

What you need to know about Louisville

The Cardinals got their ACC tourney started off right with an 84-74 win over Georgia Tech on Tuesday. Senior guard Jarrod West picked the right time to have his best game of the season, leading all scorers with 20 points. He put in work on the defensive end with four steals as well. Three other starters hit double-digit point totals in the game, led by Noah Locke, who scored 16. He was joined by Malik Williams (14 points) and Sydney Curry (12 points).

When Louisville and Virginia played each other at the end of the season, Curry scored a game-high 24 points and grabbed 14 rebounds in a losing effort for the Cardinals. Louisville shot just 40 percent from the field, while the Cavaliers made 51 percent of their attempts.

What you need to know about Virginia

Winning three games against the same team in one season is tough, but that's what Virginia is tasked with doing on Wednesday. The Cavaliers should be confident after beating the Cardinals by a combined 24 points over their previous two meetings. Kadin Shedrick ended up being the top scorer for the Cavaliers in their last game with the Cardinals, recording 20 points and five boards off the bench. Guard Reece Beekman also looked sharp, securing a double-double on 15 points and 12 rebounds in addition to five steals.

Virginia ranks 10th in college basketball when it comes to turnovers per game, with just 9.8 on average. Meanwhile, the Cardinals stumble into the game with the 41st fewest takeaways in the nation, with only 11.1 per game. 

How to make Virginia vs. Louisville picks

The model has simulated Virginia vs. Louisville 10,000 times and the results are in. We can tell you that the model is leaning over, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You can only see the pick at SportsLine.

Who wins Virginia vs. Louisville? And which side of the spread is a must-back? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks, and find out.