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The Pittsburgh Panthers and the Wake Forest Demon Deacons will face off in an ACC clash at 7 p.m. ET on Wednesday at Lawrence Joel Veterans Memorial Coliseum. Wake Forest is 17-5 overall and 12-1 at home, while the Panthers are 8-13 overall and 1-6 on the road. Wake Forest has dominated this series in recent years, winning five of the last seven matchups against the Panthers. 

The Demon Deacons are favored by 12.5-points in the latest Wake Forest vs. Pittsburgh odds from Caesars Sportsbook, and the over-under is set at 137. Before entering any Pittsburgh vs. Wake Forest picks, you'll want to see the college basketball predictions from the proven computer model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $2,400 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Wake Forest vs. Pittsburgh. You can head to SportsLine to see its picks. Here are several college basketball odds for Wake Forest vs. Pittsburgh:

  • Wake Forest vs. Pittsburgh spread: Wake Forest -12.5
  • Wake Forest vs. Pittsburgh over-under: 137 points

What you need to know about Wake Forest

The Demon Deacons suffered a grim 94-72 defeat to the Syracuse Orange this past Saturday. A silver lining for Wake Forest was the play of guard Daivien Williamson, who shot 5-for-8 from downtown and finished with 27 points. For the season, Williamson is averaging 13.4 points, 2.4 rebounds and 1.1 assists per game. 

Wake Forest is led by guard Alondes Williams, who's averaging 19.8 points, 6.8 rebounds and 5.1 assists per game. The senior guard has scored 20 or more points in five of his last eight games. The Demon Deacons have won 12 of their last 13 games at home, and they're 4-1 against the spread in their last five games when playing as the favorite. 

What you need to know about Pittsburgh

Meanwhile, the Panthers received a tough blow on Sunday as they fell 69-56 to the Boston College Eagles. Forward John Hugley wasn't much of a difference maker for Pitt; Hugley played for 29 minutes but put up just nine points on 3-for-10 shooting and eight turnovers.

Despite scoring just nine points in his last outing, Hugley leads the Panthers in scoring, averaging 15.2 points per game. He's also securing 8.4 rebounds per game on average, and he's secured six double-doubles this season. Pittsburgh has struggled mightily on the road, winning just one of its last 12 road games. 

How to make Pittsburgh vs. Wake Forest picks

The model has simulated Wake Forest vs. Pittsburgh 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 60 percent of simulations. You can only see the pick at SportsLine.

Who wins Wake Forest vs. Pittsburgh? And which side of the spread is a must-back? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks, and find out.