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LSU had a disappointing 2020 season, but it was able to go on the road and knock off No. 6 Florida. The Tigers have a chance to salvage another disappointing year when they host the No. 20 Gators on Saturday afternoon. Florida bounced back from a loss to Kentucky with a 42-0 blowout against Vanderbilt last week. LSU has dropped consecutive games to Auburn and Kentucky, falling to 3-3 on the season.

Kickoff is set for noon ET. The Gators are 12-point favorites in the latest Florida vs. LSU odds at Caesars Sportsbook, while the over-under for points scored is 59.5. Before entering any Florida vs. LSU picks, you'll want to see the college football predictions from the advanced computer model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,800 for $100 players on its top-rated college football picks against the spread. It also enters Week 7 of the 2021 season on a 19-7 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on LSU vs. Florida. You can head to SportsLine to see its picks. Here are several college football odds for Florida vs. LSU:

  • LSU vs. Florida spread: Florida -12
  • LSU vs. Florida over-under: 59.5 points
  • LSU vs. Florida money line: Florida -450, LSU +350

Why LSU can cover

LSU finally showed some life in the running game last week against Kentucky. Running back Tyrion Davis-Price, who hasn't been much of a factor this season, rushed for two touchdowns and 147 yards on 22 carries. 

This was the first time Davis-Price has racked up 100-plus rushing yards all year and it was also his first game with two rushing touchdowns. The Tigers have only averaged 83.5 rushing yards per game this season and establishing the run with Davis-Price might allow LSU to control the ball and at least keep this game within the spread. 

What you need to know about Florida

The Tigers are now 8-8 in their 16 games since winning the College Football Playoff, which has led to speculation about the job status of head coach Ed Orgeron. His team looked flat in a 21-point loss to Kentucky last week and is dealing with multiple key injuries. Wide receiver Kayshon Boutte (ankle) and top pass rusher Ali Gaye are just a couple of the key players who will be out Saturday.

Florida hurt itself against Kentucky two weeks ago, committing 15 penalties in the 20-13 loss. The Gators chopped that number in half against Vanderbilt, taking care of business in a 42-0 victory. They will have revenge on their mind after being upset by LSU last year and their lack of injuries will give them an advantage.

How to make Florida vs. LSU picks

The model is leaning over on the total and it's also generated a point-spread pick that is hitting in almost 60 percent of simulations. You can only see the pick at SportsLine.

So who wins LSU vs. Florida? And which side of the spread hits almost 60 percent of the time? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that has crushed its college football picks, and find out.