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The top two teams in the American League Central collide when the Cleveland Guardians and Chicago White Sox start a key three-game series on Tuesday at Guaranteed Rate Field. The Guardians (80-67) own a four-game lead in the division over the White Sox (76-71) entering Tuesday. After the series both teams will have just 12 regular season games remaining. Chicago is a -170 favorite in the latest White Sox vs. Guardians odds from Caesars Sportsbook, while Cleveland is a +143 underdog. The over/under for runs scored is 7.

First pitch is set for 8:10 p.m. ET in Chicago. The game is one of 16 on the MLB schedule for Tuesday. Elsewhere in the majors, Yankees slugger Aaron Judge, who has 59 home runs, continues his record-setting home run push against the Pirates, and the Dodgers and Diamondbacks play a doubleheader in Los Angeles. Before making any MLB picks or parlays, be sure to see the predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is 321-272 on top-rated MLB money-line picks since the start of the 2021 season, returning more than $600 for $100 bettors during that span. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen profitable returns.

Now, the model has locked in four confident MLB best bets for Tuesday. They all involve games at 6:40 p.m. ET or later, so there's still time to get these MLB picks in. If you successfully parlay the picks, you'd be looking at a payout of almost 25-1. You can only see the model's MLB picks at SportsLine. 

Top MLB picks today

The model, which ran 10,000 simulations on each of Tuesday's games, likes Houston (+122) to knock off Tampa Bay. The Astros (97-51) are one of the hottest teams in the majors, having gone 16-4 over their last 20 games. They have won six straight series and can clinch a seventh consecutive series with a victory on Tuesday.

Houston faces Rays LHP Shane McClanahan on Tuesday, and the Astros hit lefthanded pitching well. Houston leads the majors in home runs (66) and ranks second in the AL in OPS (.769) against lefties this season. The Astros also are a MLB-best 38-12 against southpaws. See who else to back right here.

How to make MLB picks and parlays for Tuesday

The model also locked in three other best bets for Tuesday, including a play on an even bigger AL underdog. You can see the model's MLB Tuesday best bets and parlay only at SportsLine.

What MLB picks should you target for a payout of almost 25-1? And what underdog does the model like on Tuesday? Visit SportsLine now to see the MLB best bets from an advanced model that is on a 321-272 run on top-rated MLB money-line picks since the start of 2021.