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The top two teams in the AL Central collide on Wednesday when the Minnesota Twins host the Cleveland Guardians in the second game of a three-game series at Target Field. The Twins (38-31) and Guardians (35-28) enter the game tied atop the division, with the Guardians mere percentage points ahead. Minnesota is a -160 favorite in the latest Twins vs. Guardians odds from Caesars Sportsbook while Cleveland is a +140 underdog.

First pitch is set for 7:40 p.m. ET, and the game is one of 15 on the MLB schedule for Wednesday. Elsewhere in the majors, the Dodgers' Tyler Anderson (8-0, 2.82 ERA) tries to join teammate Tony Gonsolin as the only nine-win pitchers in the majors when he faces the struggling Reds. Also, Angels two-way star Shohei Ohtani tries to win three straight starts for the first time this season when the Angels host the Royals. Before making any MLB picks or parlays, be sure to check out the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 56-47 roll on top-rated MLB money-line picks through 11 weeks. Anyone who has followed it has seen profitable returns.

Now, the model has locked in four confident MLB best bets for Wednesday. They all involve games at 7:05 p.m. ET or later, so there's still time to get these MLB picks in. If you successfully parlay the picks, you'd be looking at a payout of almost 15-1. You can see the model's MLB picks for Wednesday only at SportsLine. 

Top MLB picks today

The model, which simulated each of the 15 games on Wednesday's schedule 10,000 times, is taking Pittsburgh (+115) to beat the Cubs for the third straight day at 7:05 p.m. ET (see tickets at StubHub). In the first game of the series on Monday, the Pirates routed Chicago, 12-1, thanks to four RBI from the newly promoted Oneil Cruz. On Tuesday, Pittsburgh pounded the Cubs, 7-1, behind Bligh Madris' first major league home run.

Those two blowouts continued a bad trend for Chicago, which has lost 13 of 15 games. In the month of June, the Cubs have an ERA of 6.79. That's the worst in the majors over that time and more than 1.5 runs higher than the next worst team, Oakland (5.22).

How to make MLB parlays for Wednesday

The model also locked in three other best bets for Wednesday, including a play on an even bigger underdog than the Pirates. You can see the model's MLB Wednesday best bets and parlay only at SportsLine.

What MLB picks should you target for a payout of almost 15-1? And what big underdog does the model like on Wednesday? Visit SportsLine now to see the MLB best bets from an advanced model that is on a 56-47 roll on top-rated MLB money-line picks through 11 weeks.