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The Indiana Pacers will look to snap a 12-game losing streak when they battle the Cleveland Cavaliers in a Central Division matchup on Tuesday. Cleveland is coming off a 114-110 loss to the Detroit Pistons on Saturday, while Indiana dropped a 135-127 decision at Orlando that same day. The Cavaliers (20-17), who have won three of four, are 7-8 on the road this season. The Pacers (6-30), who are 4-18 within the Eastern Conference, are 5-14 on their home floor. Donovan Mitchell (rest) will miss the game for Cleveland, while Isaiah Jackson (concussion) is out for Indiana. Jarrett Allen (illness) has been upgraded from questionable to probable for the Cavs. 

Tipoff from Gainbridge Fieldhouse in Indianapolis is set for 7 p.m. ET. Cleveland is a 6.5-point favorite in the latest Cavaliers vs. Pacers odds from SportsLine consensus, while the over/under for total points scored is 236.5. Before making any Pacers vs. Cavaliers picks, check out the NBA predictions and betting advice from the SportsLine Projection Model.

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The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model enters Week 12 of the 2025-26 NBA season on a sizzling 33-15 roll on top-rated NBA spread picks dating back to last season. Anyone following its NBA betting advice at sportsbooks and on betting apps could have seen huge returns.    

Now, the model has simulated Cavaliers vs. Pacers 10,000 times and just revealed its coveted NBA picks and betting predictions. You can head to SportsLine now to see the model's picks. Here are several NBA odds and NBA betting lines for Pacers vs. Cavaliers:

Cavaliers vs. Pacers spread:    

Cleveland -6.5 at DraftKings    

Cavaliers vs. Pacers over/under:    

236.5 points

Cavaliers vs. Pacers money line:    

Cleveland -231, Indiana +190

Cavaliers vs. Pacers picks:    

See picks at SportsLine

Cavaliers vs. Pacers streaming:

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How to make Cavaliers vs. Pacers picks

SportsLine's model is going Under on the total (236.5 points). The total has gone Under in two of the last three head-to-head meetings. The Under has also hit in four of the last five Cavaliers games. The Cavaliers are 5-5 against the spread in their last 10 games, while the Pacers are 3-7 ATS in their last 10. The SportsLine model is projecting Cleveland's Darius Garland to score 20.4 points on average and be one of six Cavaliers players to score 11 or more points. Indiana's Pascal Siakam, meanwhile, is projected to have 28.2 points as five Pacers players score 11.5 points or more.

It has also generated an against-the-spread pick that hits in well over 50% of simulations. You can head to SportsLine to see the model's NBA picks. 

So who wins Cavaliers vs. Pacers, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the Cavaliers vs. Pacers spread to back, all from the model that has returned well over $10,000 on top-rated NBA picks, and find out.