49ers at Titans predictions: Point spread, total, player props, TV, streaming for 'Thursday Night Football'

Get ready for Week 16 with our gambling breakdown of 49ers-Titans

The San Francisco 49ers and Tennessee Titans will get Week 16 in the NFL started when these clubs go head-to-head during the final "Thursday Night Football" matchup of the 2021 regular season. The Niners have been one of the hottest teams in the league in this second have won five of their last six games. The Titans have been on the opposite side of that spectrum as they've lost three of their last four but remain in first place in the AFC South. 

Here, we'll specifically be looking at the different betting angles that this divisional matchup has in store for us. We'll be taking a look at how the lines have shifted throughout the week leading into Thursday night and, of course, give you our picks for this game along with a handful of our favorite player props. 

All NFL odds via Caesars Sportsbook.

How to watch

Date: Thursday, Dec. 23 | Time: 8:20 p.m. ET
Location: Nissan Stadium (Nashville)
TV: NFL Network | Stream: fuboTV (try for free)
Follow: CBS Sports App
Odds: 49ers -3, O/U 44

Line movement

The early look on this line had the Titans as a 1-point favorite, but that rather quickly shifted away from them and towards the 49ers. Coming out of Week 15, San Francisco rose to a 3-point favorite. That has come down some on the eve of this head-to-head with positive news surrounding both Julio Jones and possibly A.J. Brown being re-injected into this offense. 

The pick: Titans +3. I'm leaning in on the hope that both Brown and Jones will play in this game. Specifically, with Brown, the wideout completely changes out the Titans play on the offensive side of the ball and will make Tennessee that much more difficult to defend. While the 49ers have impressive pieces on that defense, they do rank 21st in the league against the pass in DVOA. The Titans could exploit that with Brown and Jones in the fold. Give me the field goal advantage with the home team taking on another club that is flying from the west coast on a short week. 

Key trend: Tennessee is 2-0 ATS this season as a home underdog.  

Over/Under total

The total opened at 43.5 and jumped up a full point to 44.5 by the end of Week 15. That number has since come down some as it now sits at 44 on Thursday morning.

The pick: Over 44. This is a slight lean towards the over as both of these teams are 7-7 on the total this season. If the Titans regain a passing attack with some players returning, that trends towards this game becoming more a higher-scoring affair. However, if they look like they did against Pittsburgh last week, Kyle Shanahan will not hesitate to triple-down on the run and bleed the clock as much as humanly possible. I expect something closer to the former, so I'll back that these two teams get over the 44-point hurdle. 

Key trend: Under is 10-4 in Titans last 14 games as an underdog. 

Jimmy Garoppolo props

• Passing touchdowns: 1.5 (Over -125, Under -105)
• Passing yards: 236.5 (Over -115, Under -115)
• Interceptions: 0.5 (Over +105, Under -135)
• Completions: 20.5 (Over -115, Under -115)
• Pass attempts: 29.5 (Over -115, Under -115)
• Longest passing completion: 36.5 (Over -110, Under -120)
• Rushing yards: 1.5 (Over -105, Under -125)

Garoppolo has been throwing the ball around quite well over these last few weeks. Coming into Week 16, he is averaging 276.7 passing yards per game over his previous three contests, so the Over on his 236.5 passing yards prop is worth a look. I don't expect that production to completely fall off a cliff and if Tennessee can keep this game close offensively -- which I believe they will -- that inherently puts more of an emphasis on the 49ers to pass the football. Garoppolo has also gone over this prop in five of his last eight games. 

Ryan Tannehill props

• Passing touchdowns: 1.5 (Over +165, Under -200)
• Passing yards: 216.5 (Over -115, Under -115)
• Interceptions: 0.5 (Over -125, Under 105)
• Completions: 20.5 (Over +105, Under -135)
• Pass attempts: 29.5 (Over -120, Under -110)
• Longest passing completion: 33.5 (Over -115, Under -115)

The 49ers rank second in the NFL in DVOA against the run, so the Titans ground attack could be stifled rather quickly in this game and force Tannehill to drop back and throw more often. Lucky for him, he may get his top two pass-catching options back in the fold and face a San Francisco secondary that is 21st in the NFL against the pass. With those factors in mind, I'm rolling Over 20.5 completions at +105 and Over 216.5 passing yards at even money. Even with the disfunction that the Tennessee passing game has dealt with this season, Tannehill has gone over this completion prop seven times and has surpassed this passing yards total in five games. 

Player props to consider

George Kittle total receiving yards: Over 67.5 (-115). This number is just too small for what Kittle has been bringing to the table over these last few weeks. In his previous three games leading into Week 16, Kittle is averaging 141.7 receiving yards per game. The passing offense flows through him and outside of this turning into a blowout where the Niners simply run out the clock, I don't see how he doesn't get over this number. 

Deebo Samuel anytime touchdown (+103). Samuel has unlocked a new piece to his game this season with his prowess out of the backfield. He's been a monster for the 49ers on the ground and has a nose for the end zone, scoring in five straight heading into Week 16. Getting someone who has that level of production in the red area at plus money should be an auto-bet.